ArticleMikrochimica acta2026
Portable origami paper-based photoacoustic-photothermal dual-mode device for on-site antioxidants detection.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Ensuring reliable detection in complex sample matrices remains a significant challenge. Dual-mode strategies offering built-in cross-validation present a promising solution. Herein, a miniaturized photoacoustic (PA)-photothermal (PT) dual-mode device was developed by integrating an origami paper-based platform and utilizing oxidized 3,3',5,5'-tetramethylbenzidine (oxTMB) as a signal probe. The CuS/g-C₃N₄ catalyzes the oxidation of colorless TMB into blue oxTMB, which generates strong PA and PT signals under 808 nm laser irradiation. Crucially, antioxidants (such as dopamine, ascorbic acid, and glutathione) inhibit the TMB oxidation, leading to a signal decrease. With a small sample volume of 15 μL and an analysis time of 30 min, the device demonstrated excellent stability, reproducibility, and accuracy. Its practical applicability was validated by the successful analysis of various real food samples. Overall, this work presents a novel dual-mode device that enables cross-validation and holds great potential for on-site food safety detection.
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