ArticleScientific reports2026
Performance on the one-minute sit-to-stand test predicts long-term adverse outcomes in pulmonary hypertension.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction The one-minute sit-to-stand test (1-min STST) is a simple and reproducible measure of functional capacity. Recently, cut-off values for the 1-min STST equivalent to guideline-recommended six-minute walk test (6MWT) thresholds have been proposed for risk stratification in patients with pulmonary hypertension (PH). However, the prognostic value of the 1-min STST for long-term outcomes remains unclear. Aim To assess the association between the 1-min STST performance and long-term adverse outcomes in patients with PH. Methods Consecutive patients with PH were prospectively enrolled and underwent both the 1-min STST and 6MWT. The primary endpoint was a composite of heart failure hospitalization, heart-lung transplantation or all-cause mortality. Associations between 1-min STST performance and long-term adverse outcomes were assessed using Cox regression. Patients were stratified into three groups based on previously published 1-min STST cut-offs (≤ 14, 15–19, ≥ 20 repetitions), aligned with 6MWT thresholds. Kaplan-Meier curves were used to compare event rates between groups. Results A total of 117 patients (mean age 66 ± 14 years, 56% female) were included. Over a median follow-up of 2.7 years [IQR 1.0–3.9], 60 (51%) patients experienced an adverse event. Lower 1-min STST performance was significantly associated with a higher risk of long-term adverse outcomes (HR per repetition: 0.94, 95% CI: 0.90–0.98, p < 0.001). This association remained significant after adjusting for age, sex, BMI and NT-proBNP levels (adjusted HR = 0.95; 95% CI: 0.91–0.99; p = 0.016) and major comorbidities (adjusted HR = 0.94; 95% CI: 0.90–0.98; p = 0.003). Kaplan-Meier analysis showed significantly worse long-term outcomes in patients performing ≤ 14 repetitions (log-rank p = 0.001). Conclusion The 1-min STST is a predictor for long-term adverse events in PH patients. Performing ≤ 14 repetitions on the 1-min STST indicates a significantly higher risk of long-term adverse outcomes. Therefore, the 1-min STST may be used for risk stratification in clinical practice.
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