Protective effects of propolis against metaflumizone induced cardiotoxicity through modulation of oxidative stress, inflammation, and the PI3K/Akt/mTOR pathway.

Mehmet Başeğmez, İnan Dursun, Adem Kara, Volkan Gelen, İrfan Çinar

Abstract read

In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Mehmet BaşeğmezLaboratory and Veterinary Health Program, Department of Veterinary, Acıpayam Vocational High School, Pamukkale University, Denizli, Turkey. mbasegmez@pau.edu.tr.

İnan DursunDepartment of Beekeeping, Vocational School of Food, Agriculture and Livestock, Bingöl, Turkey.

Adem KaraDepartment of Genetics, Faculty of Science, Erzurum Technical University, Erzurum, Turkey.

Volkan GelenDepartment of Physiology, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey.

İrfan ÇinarDepartment of Pharmacology, Faculty of Medicine, Kastamonu University, Kastamonu, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the cardiotoxic effects of metaflumizone (MTF), a commonly used pesticide, and the potential protective role of propolis (PROP) against MTF-induced cardiac damage. Twenty-eight male Wistar albino rats were randomly divided into four groups: Control, PROP (200 mg/kg), MTF (500 mg/kg), and MTF + PROP. All treatments were administered orally for 21 days. Biochemical, molecular (RT-qPCR), histopathological, and UHPLC-Orbitrap

Indexed as

CardiotoxicityOxidative StressPropolisSemicarbazonesAnimalsInflammationMaleMyocardiumPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsRats, WistarSignal TransductionTOR Serine-Threonine KinasesmTOR protein, ratPhosphatidylinositol 3-KinasesPropolisProto-Oncogene Proteins c-aktSemicarbazonesTOR Serine-Threonine KinasesApoptosisCardiacInflammationMetaflumizonePropolis extractUHPLC-Orbitrap®-HRMS

Identifiers

PMID41611877

DOI10.1007/s00204-026-04312-3

PMCPMC12967514

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.