Evidence map›Paper›PMID 41611857›Full record

ArticleScientific reports2026

Refractory eosinophilic duodenal bulb ulcer associated with Helicobacter pylori eradication in children: a multicenter study.

Zhiheng Huang, Ping Li, Ying Zhou, Min Ji, Yangyang Ma, Yingying Meng, Shengnan Wang, Cuifang Zheng, Lin Wang, Junping Lu and 7 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zhiheng Huang *Department of Gastroenterology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Ping Li *Department of Gastroenterology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Ying ZhouDepartment of Gastroenterology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Min JiDepartment of Radiology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Yangyang MaDepartment of Pathology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Yingying MengDepartment of Gastroenterology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Shengnan WangDepartment of Gastroenterology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Cuifang ZhengDepartment of Gastroenterology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Lin WangDepartment of Gastroenterology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Junping LuDepartment of Gastroenterology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Zifei TangDepartment of Gastroenterology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Zhinong JiangDepartment of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiaoqing ZhangDepartment of Gastroenterology, Children's Hospital of Suzhou University, Suzhou, China.
Xiaodong WangDepartment of Gastroenterology, Xiamen Children's Hospital National and Children's Hospital of Fudan University at Xiamen, Xiamen, China.
Peng ShiPediatric Clinical Research Unit, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Yuhuan WangDepartment of Gastroenterology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. wangyuhuan08@163.com.
Ying HuangDepartment of Gastroenterology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. yhuang815@163.com.ORCID http://orcid.org/0000-0002-4931-4006

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Refractory eosinophilic duodenal bulb ulcers (REDU) following Helicobacter pylori (HP) eradication are rarely reported. This study aimed to investigate REDU in pediatric populations post-HP eradication. This multicenter retrospective analysis included children admitted to the Gastroenterology Departments of three children’s hospitals between January 1, 2016, and August 31, 2025. Eligible cases were pediatric patients diagnosed with REDU across the three centers. For the REDU group, clinical characteristics, laboratory tests, endoscopic findings, HP treatment strategies, and follow-up data were analyzed. Thirty patients (mean age 10.0 ± 3.4 years) were diagnosed with REDU, including 19 with HP eradication-related REDU and 11 with idiopathic REDU. Compared with HP-associated duodenal bulb ulcer (DBU) control group, the HP eradication-related REDU group had higher rates of anemia, elevated peripheral blood eosinophils (EOS) count, endoscopic giant DBU, bulbar stenosis, repeated endoscopies, and HP eradication therapies (all P < 0.01). REDU patients presented with punched-out DBU featuring a clean, thin white base; 76.7% (23/30) of REDU patients had giant DBU. Before treatment, among the entire REDU cohort, EOS counts 100 cells/HPF were noted in 17 cases (56.7%), while counts ≥ 50 cells/HPF were observed in 13 cases (43.3%). Serum cytokine assay showed that IL-8 was significantly elevated. All patients were treated with dietary avoidance and proton pump inhibitor (PPI) therapy. Recurrence was common, occurring in 9 of 16 patients (56.2%) following PPI dose reduction or discontinuation, with a median interval of 50.0 [35.0, 120.0] days. HP eradication may be associated with REDU in children via eosinophilic infiltration, emphasizing the need for systematic monitoring of immune-related complications post-eradication.

Indexed as

Duodenal UlcerEnteritisEosinophiliaHelicobacter InfectionsHelicobacter pyloriAdolescentAnti-Bacterial AgentsChildEosinophilsFemaleHumansMaleProton Pump InhibitorsRetrospective StudiesAnti-Bacterial AgentsProton Pump InhibitorsChildrenEosinophilic gastrointestinal disordersHelicobacter pyloriProton pump inhibitorRefractory duodenal ulcer

Identifiers

PMID41611857
PMCPMC12909989

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.