Genetic predisposition to elevated total immunoglobulin E levels defines a distinct adult-onset-predominant asthma phenotype.

Takashi Matsuda, Hironori Masuko, Yu Ozawa, Rie Shigemasa, Haruna Kitazawa, Yohei Yatagai, Nobuyuki Hizawa

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Takashi MatsudaDepartment of Respiratory Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.

Hironori MasukoDepartment of Respiratory Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan. hmasuko@md.tsukuba.ac.jp.

Yu OzawaDepartment of Respiratory Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.

Rie ShigemasaDepartment of Respiratory Medicine, Kasumigaura Medical Center, Ibaraki, Japan.

Haruna KitazawaDepartment of Respiratory Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.

Yohei YatagaiDepartment of Respiratory Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.

Nobuyuki HizawaDepartment of Respiratory Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asthma heterogeneity remains a major barrier in precision medicine. Although elevated total serum immunoglobulin E (IgE) is a hallmark of asthma, even in nonatopic patients, its causal role in asthma pathogenesis is debated. We hypothesized that genetic predisposition to increased IgE defines a distinct asthma endotype. A genome-wide association study of total serum IgE in 1,287 non-asthmatic Japanese adults was used to construct IgE polygenic risk scores (IgE_PRS). Applying IgE_PRS to 745 patients with asthma, we performed cluster analysis incorporating age at onset, total IgE levels, IgE_PRS, and percent predicted forced expiratory volume in 1 s (pFEV

Indexed as

AsthmaGenetic Predisposition to DiseaseImmunoglobulin EAdultAge of OnsetFemaleGenetic Risk ScoreGenome-Wide Association StudyHumansMaleMiddle AgedPhenotypePolymorphism, Single NucleotideRetrospective StudiesImmunoglobulin EAsthmaGenome-wide association studyIgE polygenic risk scoresImmunoglobulin E

Identifiers

PMID41611806

DOI10.1038/s41598-026-37679-5

PMCPMC12913924

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.