Evidence map›Paper›PMID 41611804›Full record

ArticleScientific reports2026

Swimming is superior to running in inducing physiological cardiac hypertrophy and enhancing myocardial performance.

Amanda Yoshizaki, Ednei Luiz Antonio, Luis Dos Santos, Mariana Teixeira Dos Santos, Flavia Leticia Martins, Regiane Santos Feliciano, Jose Antonio Silva Junior, Brunno Lemes de Melo, Danilo Sales Bocalini, Paulo José Ferreira Tucci and 2 more

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Amanda YoshizakiCardiology Division, Federal University of São Paulo, São Paulo, Brazil.
Ednei Luiz AntonioCardiology Division, Federal University of São Paulo, São Paulo, Brazil.
Luis Dos SantosPurdue University College of Veterinary Medicine, West Lafayette, IN, USA. dossantos@purdue.edu.ORCID http://orcid.org/0000-0002-9964-9242
Mariana Teixeira Dos SantosCardiology Division, Federal University of São Paulo, São Paulo, Brazil.
Flavia Leticia MartinsLaboratory of Genetics and Molecular Cardiology, University of São Paulo Medical School, Heart Institute (InCor), São Paulo, Brazil.
Regiane Santos FelicianoNove de Julho University, São Paulo, Brazil.
Jose Antonio Silva JuniorNove de Julho University, São Paulo, Brazil.
Brunno Lemes de MeloCardiology Division, Federal University of São Paulo, São Paulo, Brazil.
Danilo Sales BocaliniPhysical Education and Sports Center, Federal University of Espirito Santo, Espirito Santo, Brazil.
Paulo José Ferreira TucciCardiology Division, Federal University of São Paulo, São Paulo, Brazil.
Adriana Castello Costa GirardiLaboratory of Genetics and Molecular Cardiology, University of São Paulo Medical School, Heart Institute (InCor), São Paulo, Brazil.
Andrey Jorge SerraCardiology Division, Federal University of São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aerobic exercise training (AET) can induce cardiac hypertrophy, but the specific adaptive response for different types of AET remains unclear. We evaluated nonsingular cardiac remodeling in rats through running (RT) and swimming (ST) training at approximately 75% of VO₂max. Male Wistar rats (8-10 weeks old; ~ 250 g) were divided into untrained (UT), RT, and ST groups. The RT and ST were performed five days a week, once daily for 60 min for eight weeks. Cardiopulmonary fitness was assessed by measuring maximal oxygen consumption and swimming time to exhaustion. Echocardiography evaluated left ventricular parameters, while myocardial mechanics were assessed through the papillary muscle. Histology and Western blotting were performed to evaluate cardiomyocyte size and proteins modulating phosphoinositide 3-kinase (PI3K

Indexed as

CardiomegalyHeartMyocardiumPhysical Conditioning, AnimalRunningSwimmingAnimalsCardiomegaly, Exercise-InducedMaleMicroRNAsMyocytes, CardiacOxygen ConsumptionPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsRats, WistarMicroRNAsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktCardiac physiologyMyocardial performanceRunning trainingSwimming training

Identifiers

PMID41611804
PMCPMC12914034

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.