Evidence map›Paper›PMID 41611789›Full record

ReviewNPJ precision oncology2026

A unified framework for pre-screening and screening tools in oncology clinical trials.

Denis Horgan, Joseph N Paulson, Arturo Loaiza-Bonilla, Christer Svedman, Umberto Malapelle, Frédérique Penault-Llorca, Hadi Mohamad Abu Rahsheed, Paul Hofman, Stan Kachnowski, Daniel Schneider and 1 more

Abstract readReview
In one paragraph

Review in NPJ precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Observational
  3. Digital Tools and Strategies for Engaging Patients in Cancer Clinical Trials.Cancer control : journal of the Moffitt Cancer Center
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Denis HorganEuropean Alliance for Personalised Medicine, Brussels, Belgium.
Joseph N PaulsonYale University, New Haven, CT, USA.
Arturo Loaiza-BonillaMassive Bio, Boca Raton, FL, USA. arturolb@massivebio.com.
Christer SvedmanN-Power Medicine, Redwood City, CA, USA.
Umberto MalapelleUniversity Federico II of Naples, Naples, Italy.
Frédérique Penault-LlorcaCentre Jean Perrin, Clermont-Ferrand cédex, France.
Hadi Mohamad Abu RahsheedProfessional Development Department, Qatar Cancer Society, Doha, Qatar.
Paul HofmanIHU RespirERA, FHU OncoAge, Laboratory of Clinical and Experimental Pathology, Pasteur Hospital, University Côte d'Azur, Nice, France.
Stan KachnowskiHITLAB, Healthcare Innovation & Technology Lab, Columbia University, New York, NY, USA.
Daniel SchneiderJohnson and Johnson, Raritan, NY, USA.
Vivek SubbiahSarah Cannon Research Institute, Nashville, TN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical trial enrollment in oncology remains limited by increasingly complex eligibility criteria, biomarker stratification, and fragmented clinical data, contributing to prolonged recruitment timelines and low participation rates. This review examines contemporary pre-screening and screening approaches, spanning manual workflows, health-system-embedded digital tools, and emerging artificial intelligence-enabled methods. We assess the relative strengths and limitations of large language model-based strategies, including retrieval-augmented and domain-adapted approaches, in addressing scalability, accuracy, and equity challenges. Hybrid frameworks that integrate automated screening with clinician oversight appear most effective in improving trial matching efficiency, representativeness, and timely access to investigational therapies across diverse oncology populations.

Identifiers

PMID41611789
PMCPMC13056990

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.