Evidence map›Paper›PMID 41611735›Full record

ArticleNPJ Parkinson's disease2026

The graded effect of propofol in electrophysiology-guided navigation during deep brain stimulation surgery.

G Issabekov, B Al-Fatly, M Mousavi, J Roediger, R Köhler, J Habets, A L de Almeida Marcelino, M S Tuncer, P Krause, M Astalosch and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

G IssabekovMovement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin, Berlin, Germany.
B Al-FatlyMovement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin, Berlin, Germany.
M MousaviTechnische Universität, Berlin, Germany.
J RoedigerMovement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin, Berlin, Germany.
R KöhlerMovement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin, Berlin, Germany.
J HabetsMovement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin, Berlin, Germany.
A L de Almeida MarcelinoMovement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin, Berlin, Germany.
M S TuncerMovement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin, Berlin, Germany.
P KrauseMovement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin, Berlin, Germany.
M AstaloschMovement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin, Berlin, Germany.
D Kübler-WellerMovement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin, Berlin, Germany.
C SpiesDepartment of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité - Universitätsmedizin, Berlin, Germany.
P SpindlerDepartment of Neurosurgery, Charité - Universitätsmedizin, Berlin, Germany.
K FaustNeurosurgical Clinic, Heinrich-Heine-University, Düsseldorf, Germany.
P TruckenmuellerDepartment of Neurosurgery, Charité - Universitätsmedizin, Berlin, Germany.
G H SchneiderDepartment of Neurosurgery, Charité - Universitätsmedizin, Berlin, Germany.
A A Kühn *Movement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin, Berlin, Germany.
L A Steiner *Movement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin, Berlin, Germany. leon-amadeus.steiner@charite.de.ORCID http://orcid.org/0000-0002-0953-9235

Funding

Deutsche Forschungsgemeinschaft 424778381 - TRR 295Hertie Foundation P1230041
6 · The paper itself

Abstract

Propofol is widely used for general anesthesia (GA) during deep brain stimulation (DBS) surgery targeting the subthalamic nucleus (STN) in Parkinson's disease (PD), yet its effects on intra-operative spatial navigation, critical for electrode placement, remain contentious. We performed multimodal analysis on 583 microelectrode recordings (MER) from PD patients undergoing DBS surgery under local anesthesia (LA) and GA. Deep sedation interfered with the identification of the dorsal STN border, and propofol dosages >4 mg/kg/h resulted in deeper final electrodes. While firing rate (FR) and burst index (BI) differed between LA and GA, only BI distinguished imaging-defined STN and correlated negatively with the proximity to the DBS sweetspot across conditions. Thus, propofol-based GA complicates navigation in DBS surgery, but MER remain informative if propofol levels are carefully controlled. BI emerges as a potential biomarker when MER are "polluted" by high levels of propofol, offering critical feedback during DBS surgery under GA.

Identifiers

PMID41611735
PMCPMC12992798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.