Evidence map›Paper›PMID 41611729›Full record

ArticleNPJ breast cancer2026

The association between local therapies and survival among patients with metastatic inflammatory breast cancer.

Tanun Jitwatcharakomol, Yevgeniya Gokun, Steve A Walston, Samilia Obeng-Gyasi, Rebekah L Young, Therese Y Andraos, Kaidi Wang, Sasha J Beyer, Sachin R Jhawar, Jacob M Eckstein

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ breast cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tanun JitwatcharakomolDivision of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Yevgeniya GokunCenter for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Steve A WalstonDepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Samilia Obeng-GyasiDivision of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Rebekah L YoungDepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Therese Y AndraosDepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Kaidi WangDepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Sasha J BeyerDepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Sachin R JhawarDepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Jacob M EcksteinDepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Jacob.Eckstein@osumc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory breast cancer (IBC) is an aggressive subtype with early metastatic spread. This study evaluated whether adding adjuvant radiation therapy (RT) to surgery and chemotherapy improves survival in metastatic IBC using the National Cancer Database (2010-2021). A total of 3219 patients were categorized into four groups: chemotherapy alone; chemotherapy plus surgery; chemotherapy plus RT; and trimodality therapy (chemotherapy and surgery followed by RT). Median follow-up was 23.6 months. Two-year overall survival was 51.8% (chemotherapy alone), 57.8% (chemotherapy + surgery), 36.5% (chemotherapy + RT), and 73% (trimodality therapy). Compared with chemotherapy + surgery, chemotherapy alone and chemotherapy + RT were associated with higher mortality, while adding adjuvant RT after chemotherapy + surgery (trimodality therapy) was not associated with improved survival. In subgroup analysis, adding PMRT to surgery and chemotherapy in those with positive surgical margins was associated with improved survival compared with surgery and chemotherapy alone, adjusting for age (aHR 0.57; 95% CI: 0.34-0.97). Further research is needed to understand the role of local therapy in metastatic IBC.

Identifiers

PMID41611729
PMCPMC12957309

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.