Evidence map›Paper›PMID 41611679›Full record

ArticleNature communications2026

ALKB-1-dependent tRNA methylation is required for efficient paternal mitochondrial elimination.

Zhenhuan Luo, Yimin Li, Chenyang He, Dan Wu, Wenyu Dai, Liubing Hu, Jing Yang, Brian L Harry, Zhenyu Ju, Nektarios Tavernarakis and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. DNA Repair Mechanisms.Methods in molecular biology (Clifton, N.J.) · 2027
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhenhuan Luo *Department of Cardiology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China.ORCID 0000-0003-1375-0882
Yimin Li *Department of pathogen biology, school of medicine, Jinan University, Guangzhou, Guangdong, China.
Chenyang HeShantou Clinical Medical College of Jinan University (Shantou Central Hospital), Jinan University, Shantou, Guangdong, China.
Dan WuShantou Clinical Medical College of Jinan University (Shantou Central Hospital), Jinan University, Shantou, Guangdong, China.
Wenyu DaiShantou Clinical Medical College of Jinan University (Shantou Central Hospital), Jinan University, Shantou, Guangdong, China.ORCID 0000-0003-4669-5787
Liubing HuThe Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, China.
Jing YangCollege of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.ORCID 0000-0002-9498-608X
Brian L HarryDepartment of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-7947-3908
Zhenyu JuKey Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regeneration Medicine, Jinan University, Guangzhou, Guangdong, China.ORCID 0000-0002-9525-6521
Nektarios TavernarakisInstitute of Molecular Biology and Biotechnology, Foundation of Research and Technology-Hellas Department of Basic Sciences, School of Medicine, University of Crete Heraklion, Crete, Greece.ORCID 0000-0002-5253-1466
Hao WangShantou Clinical Medical College of Jinan University (Shantou Central Hospital), Jinan University, Shantou, Guangdong, China. haowang@jnu.edu.cn.ORCID 0000-0003-2169-1712
Qin-Li WanDepartment of pathogen biology, school of medicine, Jinan University, Guangzhou, Guangdong, China. wanqinli@hotmail.com.ORCID 0000-0003-2864-912X
Qinghua ZhouShantou Clinical Medical College of Jinan University (Shantou Central Hospital), Jinan University, Shantou, Guangdong, China. gene@email.jnu.edu.cn.ORCID 0000-0003-0468-9266

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal mitochondrial inheritance is secured by mechanisms that exclude paternal mitochondrial DNA (mtDNA). While, epigenetic modifications are vital for spermatogenesis and embryo development, their roles in the paternal mitochondrial elimination (PME) remain poorly understood. Here, we identify ALKB-1, a DNA/RNA demethylase, as a pivotal factor for efficient PME in Caenorhabditis elegans (C. elegans), acting through ALKB-1-dependent modulation of tRNA m

Indexed as

AlkB EnzymesCaenorhabditis elegansCaenorhabditis elegans ProteinsMitochondriaPaternal InheritanceRNA, TransferAnimalsDNA, MitochondrialEpigenesis, GeneticEpitranscriptomeMaleMethylationOxidative StressReactive Oxygen SpeciesRNA MethylationSpermatozoaAlkB EnzymesCaenorhabditis elegans ProteinsDNA, MitochondrialReactive Oxygen SpeciesRNA, Transfer

Identifiers

PMID41611679
PMCPMC12957315

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.