Evidence map›Paper›PMID 41611672›Full record

Trial reportNature communications2026

Spinal cord stimulation therapy for gait impairment in Parkinson's disease: a double-blinded, randomised feasibility trial with an open extension.

Miriam Højholt Terkelsen, Victor S Hvingelby, Erik L Johnsen, Mette Møller, Erik Hvid Danielsen, Tove Henriksen, Andreas Nørgaard Glud, Yen Tai, Andreas M Baun, Anne Lene Knudsen and 11 more

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05110053 (Spinal Cord sTimulation thEraPy for Parkinson's Disease Patients With Gait Problems), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05110053 nacompletednot on this map

Spinal Cord sTimulation thEraPy for Parkinson's Disease Patients With Gait Problems

TypeinterventionalSponsorUniversity of AarhusRan2021 to 2024Enrolled12ConditionsParkinson Disease, Gait Disorders, Neurologic, Fall InjuryArmsSpinal Cord Stimulation
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Miriam Højholt Terkelsen *Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0003-0971-3747
Victor S Hvingelby *Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Erik L JohnsenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Mette MøllerDepartment of Neurology, Aarhus University Hospital, Aarhus, Denmark.
Erik Hvid DanielsenDepartment of Neurology, Aarhus University Hospital, Aarhus, Denmark.
Tove HenriksenDepartment of Neurology, Bispebjerg Hospital, Copenhagen, Denmark.
Andreas Nørgaard GludDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0003-3339-6120
Yen TaiDepartment of Neurosciences, Imperial College Healthcare NHS Trust, London, UK.
Andreas M BaunDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0009-0007-8099-1367
Anne Lene KnudsenDepartment of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark.
Rikke Nan ValdemarsenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0009-0004-7349-4459
Jacob HorsagerDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Niels OkkelsDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-6483-9505
Anne Sofie Møller AndersenDepartment of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark.
Kaare MeierDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-7677-406X
Per BorghammerDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-6391-8052
Sophie MolloyDepartment of Neurosciences, Imperial College Healthcare NHS Trust, London, UK.
Dipankar NandiDepartment of Neurosciences, Imperial College Healthcare NHS Trust, London, UK.
Elena MoroGrenoble Alpes University, Division of Neurology, CHU of Grenoble, Grenoble Institute of Neurosciences, Grenoble, France.
Jens Christian Hedemann SørensenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-5139-7405
Nicola PaveseDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark. npavese@clin.au.dk.ORCID 0000-0002-6801-6194

Funding

Det Frie Forskningsråd (Danish Council for Independent Research) 0134-00305B
6 · The paper itself

Abstract

A trial of spinal cord stimulation (SCS) was performed in people with gait-impaired Parkinson's (ClinicalTrials.gov: NCT05110053 ). Fourteen patients underwent gait assessments and [

Indexed as

Gait Disorders, NeurologicParkinson DiseaseSpinal Cord StimulationAgedDouble-Blind MethodFeasibility StudiesFemaleFluorodeoxyglucose F18GaitHumansMaleMiddle AgedPositron-Emission TomographyPostural BalanceQuality of LifeTreatment OutcomeFluorodeoxyglucose F18

Identifiers

PMID41611672
PMCPMC12960713

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.