Evidence map›Paper›PMID 41611669›Full record

ArticleNature communications2026

Stereoselective cyano translocation reaction enabled by photoenzymatic catalysis.

Xinyu Duan, Jie Xu, Rulin Bai, Chenlu Jin, Yuchen Chu, Guojing Wu, Liangliang Pan, Chunlei Yang, Zhiguo Wang, Jian Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinyu Duan *Zhejiang Key Laboratory of Bioorganic Synthesis, State Key Laboratory of Green Chemical Synthesis and Conversion, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, PR China.
Jie Xu *Zhejiang Key Laboratory of Bioorganic Synthesis, State Key Laboratory of Green Chemical Synthesis and Conversion, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, PR China.
Rulin Bai *Zhejiang Key Laboratory of Bioorganic Synthesis, State Key Laboratory of Green Chemical Synthesis and Conversion, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, PR China.
Chenlu JinZhejiang Key Laboratory of Bioorganic Synthesis, State Key Laboratory of Green Chemical Synthesis and Conversion, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, PR China.
Yuchen ChuZhejiang Key Laboratory of Bioorganic Synthesis, State Key Laboratory of Green Chemical Synthesis and Conversion, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, PR China.
Guojing WuZhejiang Key Laboratory of Bioorganic Synthesis, State Key Laboratory of Green Chemical Synthesis and Conversion, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, PR China.
Liangliang PanZhejiang Key Laboratory of Bioorganic Synthesis, State Key Laboratory of Green Chemical Synthesis and Conversion, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, PR China.
Chunlei YangZhejiang Key Laboratory of Bioorganic Synthesis, State Key Laboratory of Green Chemical Synthesis and Conversion, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, PR China. chunleiyang@zjut.edu.cn.
Zhiguo WangInstitute of Ageing Research, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, PR China. zhgwang@aliyun.com.ORCID 0000-0001-8732-4451
Jian XuZhejiang Key Laboratory of Bioorganic Synthesis, State Key Laboratory of Green Chemical Synthesis and Conversion, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, PR China. jianxu@zjut.edu.cn.ORCID 0000-0003-1765-9701

Funding

National Natural Science Foundation of China (National Science Foundation of China) No. 22322705
6 · The paper itself

Abstract

Functional-group translocation constitutes a powerful strategy in organic synthesis, allowing precise modification of molecular architectures and functional group positions. Nevertheless, methodologies capable of delivering precise stereocontrol during such migrations remain exceedingly scarce. Herein, we present a photoenzymatic strategy for cyano translocation that achieves precise stereocontrol. The use of stereo-complementary enzymes grants access to both enantiomers, while mechanistic studies and molecular dynamics simulations delineate the origin of stereoselectivity. This work expands the paradigm of transformations that can be rendered asymmetric by photoenzymatic catalysis and provides a new strategy to tackle persistent challenges in organic synthesis.

Indexed as

CatalysisMolecular Dynamics SimulationStereoisomerism

Identifiers

PMID41611669
PMCPMC12957386

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