Evidence map›Paper›PMID 41611646›Full record

ReviewHistopathology2026

Molecular pathology of phyllodes tumours of the breast-much more than MED12.

Jia-Min B Pang, Kylie L Gorringe, Puay Hoon Tan, Stephen B Fox

Abstract readReview
In one paragraph

Review in Histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jia-Min B PangPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-3466-7431
Kylie L GorringePeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0001-5681-2022
Puay Hoon TanLuma Medical Centre, KK Women's and Children's Hospital and Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID https://orcid.org/0000-0002-1052-8605
Stephen B FoxPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-7648-8896

Funding

National Health and Medical Research Council
6 · The paper itself

Abstract

Phyllodes tumours of the breast present challenges in their diagnosis, classification and management. Further understanding of the molecular changes underpinning these tumours may lead to more precise classification and potential treatment options. Similar to fibroadenomas, MED12 is the most frequently mutated gene in phyllodes tumour. However, in addition, there is a spectrum of molecular alterations from benign to malignant phyllodes tumours with increasing genomic complexity, high level copy number alterations and aberrations of cancer driver genes in malignant phyllodes tumours. This review summarizes the molecular pathology of phyllodes tumours, the use of these data in developing a model of phyllodes tumour pathogenesis, and how molecular pathology might be applied to aid diagnosis and guide treatment in this rare tumour type.

Indexed as

Breast NeoplasmsMediator ComplexPhyllodes TumorFemaleHumansMutationPathology, MolecularMED12 protein, humanMediator Complexbreastmolecular pathologyphyllodes tumour

Identifiers

PMID41611646
PMCPMC13051455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.