Evidence map›Paper›PMID 41611645›Full record

ArticleAnnals of clinical and translational neurology2026

A 73-Year-Old Man With Several Years of Difficulty Climbing Stairs and Frequent Tripping.

Mehmet Can Sari, Arens Taga, Sonya Ulrike Steele, Ahmet Hoke

Abstract readCase Reports
In one paragraph

Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mehmet Can SariDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0009-0008-4789-9558
Arens TagaDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Sonya Ulrike SteeleDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ahmet HokeDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-1215-3373

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 73-year-old man presented with progressive weakness and atrophy predominantly affecting the distal finger flexors and quadriceps muscles. Electrophysiological studies demonstrated mixed myogenic and neurogenic features. Muscle MRI showed inflammatory changes, and muscle biopsy revealed granulomatous myositis with histologic features characteristic of inclusion body myositis (IBM), including rimmed vacuoles, TDP-43 mislocalization, and autophagy activation. Additional extensive laboratory and imaging workup ruled out systemic etiologies. An empiric trial of high-dose corticosteroids yielded no clinical improvement. The diagnostic challenge stemmed from the broad differential diagnosis of granulomatous myositis and the possibility that non-IBM etiologies might be responsive to immunosuppressive treatment. This case underscores the importance of integrating clinical, electrophysiologic, radiologic, and histopathologic findings to accurately diagnose and manage granulomatous myositis.

Indexed as

Myositis, Inclusion BodyAgedHumansMaleIBMrimmed vacuolessarcoidosisTDP43

Identifiers

PMID41611645
PMCPMC13161883

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.