ArticleLupus science & medicine2026
Trajectories of long-term eGFR and proteinuria in lupus nephritis: a real-world biopsy-proven cohort study.
Article in Lupus science & medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- HLA Profiles of Patients With Chronic Kidney Disease in Central South Africa.International journal of nephrology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe long-term trajectories of estimated glomerular filtration rate (eGFR) and their relation to early proteinuria trajectories in biopsy-proven lupus nephritis (LN) are unclear. We aimed to identify eGFR trajectories and examine their association with 24-hour urine protein (24hUP) trajectories.
methodsIn this retrospective single-centre cohort, 215 adults with class III/IV (±V) LN were followed from the date of their initial renal biopsy. eGFR and 24hUP trajectories were modelled using latent class trajectory models, and associations with clinical and pathologic features were assessed. Multinomial logistic regression was used to identify baseline predictors of trajectory membership.
resultsThree eGFR trajectories were identified: stable (87.9%), late-decline (7.0%) and persistent-decline (5.1%). Persistent-decline patients had a higher chronicity index (p<0.01) and baseline serum creatinine (p=0.03), and a higher chronicity index independently predicted persistent-decline (OR 1.64; 95% CI 1.24 to 2.18). The late-decline group had higher baseline eGFR (p=0.03) and more frequent proteinuric flares (91% vs 25% for stable, p<0.01). Three 24hUP trajectories were identified: low-decreasing (81.5%), high-decreasing (11.4%) and high-increasing (7.1%). eGFR late/persistent-decline trajectories were associated with high-decreasing/increasing 24hUP trajectories (p<0.001). Notably, 48% of patients with declining eGFR achieved complete proteinuria response within 12 months, and 38% met criteria for complete renal response, despite long-term eGFR deterioration.
conclusionDistinct long-term trajectories of eGFR and proteinuria exist in LN. Short-term responses in eGFR and proteinuria may not reliably predict long-term renal outcomes, highlighting the need for more robust biomarkers to improve risk stratification and management in LN.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.