Evidence map›Paper›PMID 41611131›Full record

ArticleJournal of lipid research2026

Kiss1-FASN participates fatty acid synthesis via high-fat diet in PgVAT of female mice.

Xuehan Li, Chunyu Liang, Ge Song, Yihsuan Lin, Yue Chen, Jiani Zhao, Hongtao Sui, Xinliang Pan, Lingyu Sun, Jianhao Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xuehan LiSport Science School, Beijing Sport University, Beijing, China; Capital University of Physical Education and Sports, Sports Artificial Intelligence Institute, Beijing, China; Beijing Kupei Sports Culture Corp Ltd, Beijing, China.
Chunyu LiangSport Science School, Beijing Sport University, Beijing, China; school of Physical Education, Guangxi University, Nanning, China.
Ge SongSport Science School, Beijing Sport University, Beijing, China.
Yihsuan LinSport Science School, Beijing Sport University, Beijing, China.
Yue ChenSport Science School, Beijing Sport University, Beijing, China.
Jiani ZhaoSport Science School, Beijing Sport University, Beijing, China.
Hongtao SuiSport Science School, Beijing Sport University, Beijing, China.
Xinliang PanSport Science School, Beijing Sport University, Beijing, China; School of Physical Education, Xi'an University of Architecture and Technology, Xian, China.
Lingyu SunSport Science School, Beijing Sport University, Beijing, China; School of Physical Education, China University of Mining and Technology, Xuzhou, China.
Jianhao ChenSport Science School, Beijing Sport University, Beijing, China.
Jiaqi LiSport Science School, Beijing Sport University, Beijing, China.
Zhen NiSport Science School, Beijing Sport University, Beijing, China.
Yi YanSport Science School, Beijing Sport University, Beijing, China; Key Laboratory of Exercise and Physical Fitness (Beijing Sport University), Ministry of Education, Beijing, China; Laboratory of Sports Stress and Adaptation of General Administration of Sport, Beijing, China. Electronic address: yanyi@bsu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term consumption of high-fat diet (HFD) leads to energy surplus, resulting in excessive adipose tissue (AT) accumulation and dysfunction. Kiss1 is known to play a role in the metabolic regulation of AT. To explore the involvement of Kiss1 in mediating the effects of energy surplus induced by HFD, we conducted an 8-week intervention combining aerobic exercise and HFD in mice with AT-specific knockout (KO) and overexpression of Kiss1, along with HFD treatment in Kiss1-KO 3T3-L1 cells. Our results revealed that in perigonadal visceral AT (PgVAT) of female mice, the expression of Kiss1 and FASN is positively correlated. In addition, Kiss1 participate the fatty acid (FA) synthesis pathway in PgVAT of female mice. When we overexpressed Kiss1 in ATs of female mice, we found that aerobic exercise reduced FASN levels by downregulating Kiss1 expression in PgVAT, thereby may suppressing the FA synthesis capacity. This study provides novel insights for developing targeted therapeutic strategies against obesity and associated metabolic disorders.

Indexed as

Diet, High-FatFatty AcidsFatty Acid Synthase, Type IIntra-Abdominal FatKisspeptins3T3-L1 CellsAnimalsFemaleMiceMice, Inbred C57BLMice, KnockoutFasn protein, mouseFatty AcidsFatty Acid Synthase, Type IKiss1 protein, mouseKisspeptinsadipose tissueaerobic exerciseFASNhigh-fat dietKiss1

Identifiers

PMID41611131
PMCPMC13330030

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.