Evidence map›Paper›PMID 41611128›Full record

ArticleJournal of global antimicrobial resistance2026

Genomic epidemiology of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Mwanza, Tanzania.

Vitus Silago, Benson R Kidenya, Katarina Oravcova, Louise Matthews, Conjester I Mtemisika, Stephen E Mshana, Heike Claus, Jeremiah Seni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of global antimicrobial resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vitus SilagoDepartment of Microbiology and Immunology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania; Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany. Electronic address: vsilago@bugando.ac.tz.
Benson R KidenyaDepartment of Biochemistry and Molecular Biology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Katarina OravcovaSchool of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.
Louise MatthewsSchool of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.
Conjester I MtemisikaDepartment of Molecular Biology, Clinical Laboratory, Bugando Medical Centre, Mwanza, Tanzania.
Stephen E MshanaDepartment of Microbiology and Immunology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Heike ClausInstitute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Jeremiah SeniDepartment of Microbiology and Immunology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExtended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) and Klebsiella pneumoniae (ESBL-KP) represent major clinical threats globally. Genomic epidemiological data remain scarce in low- and middle-income countries, limiting a comprehensive understanding of antimicrobial-resistant pathogen diversity and clonal distribution. The present study investigated the genomic epidemiology of ESBL-EC and ESBL-KP isolates in Mwanza, Tanzania.

methodsThis cross-sectional hospital-based study employed whole-genome sequencing to characterise ESBL-EC (n = 39) and ESBL-KP (n = 49) isolated from patients with bloodstream, urinary tract, and wound infections at a zonal referral hospital between June 2019-June 2020 and March-August 2023.

resultsThirteen sequence types (STs) were identified among ESBL-EC, predominantly ST131 (30.7%) and ST648 (28.2%). ESBL-KP comprised 15 STs, with ST2390 (24.5%) and ST17 (18.4%) being the most common. The bla

conclusionThis study highlights clonal clusters, the first report of ESBL-KP ST2390, and the predominance of the virulent high-risk clone ESBL-EC ST131 in Mwanza, Tanzania. Underscoring the critical need for reinforced infection control strategies and genomic surveillance.

Indexed as

beta-LactamasesEscherichia coliEscherichia coli InfectionsKlebsiella InfectionsKlebsiella pneumoniaeAnti-Bacterial AgentsCross-Sectional StudiesDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsMolecular EpidemiologyPhylogenyTanzaniaWhole Genome SequencingAnti-Bacterial Agentsbeta-LactamasesBacterial genomic evolutionClonal diversityE. coliExtended-spectrum beta-lactamaseKlebsiella pneumoniaeWhole genome sequencing

Identifiers

PMID41611128
PMCPMC13017690

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.