ArticleJournal of advanced research2026
An injectable microsphere-reinforced system for sustained delivery of Adipo-MBV in adipose tissue engineering.
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Injectable microsphere-based delivery strategies for stem cells and their derivatives in tissue regeneration.Bioactive materials · 2026Review
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Authors and funding
8 authors.
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Abstract
introductionTissue engineering has become prominence in soft tissue reconstruction. Adipogenesis and angiogenesis are important in the formation of engineering adipose tissue. Although acellular adipose matrix (AAM) possesses potential in adipogenic induction, obvious limitations remain in the realization of the authentic physiological regeneration. Matrix-bound nanovesicles (MBVs), located on the extracellular matrix (ECM) scaffold, provide cues for the adipogenesis property of AAM. The bioactive components within ECM are influenced by the isolation procedures.
objectiveThis study aimed to extract and identify adipose-derived MBVs (Adipo-MBVs) from adipose ECM scaffolds and clarify their effective role in engineering adipose tissue formation.
methodsAdipo-MBVs were extracted from two types of adipose ECM, including chemically decellularized matrix (i.e., AAM) and mechanically concentrated ECM (i.e., adipose collagen fragment, ACF). The influence of Adipo-MBVs on cell functions were estimated in vitro. In addition, AAM-hyaluronic acid methacrylate (HAMA) hybrid hydrogel (A/H) with polydopamine (PDA)-coated HAMA microspheres (PDA@HMs) was designed to sustainedly release Adipo-MBVs in an animal model.
resultsThe results showed that Adipo-MBVs effectively recapitulated AAM effects on the construction of engineering adipose tissue. Crucially, mechanical Adipo-MBVs (M-AT-MBVs) derived from mechanically concentrated ECM exhibited a significantly stronger capacity to induce both adipogenesis and angiogenesis in vitro and in vivo, compared to chemical Adipo-MBVs (C-AT-MBVs) from chemically decellularized matrix. Furthermore, we developed a novel composite delivery system that ensured the sustained release of M-AT-MBVs and robustly promoted the regeneration of vascularized adipose tissue in a mouse model. This enhanced efficacy of M-AT-MBVs was associated with their distinct miRNA profile, particularly an enrichment of pro-adipogenic miR-143, and involved the downregulation of MAPK signaling pathway.
conclusionThis study demonstrated Adipo-MBVs as key regenerative components of adipose ECM. It is shown that mechanical isolation yields superior M-AT-MBVs, and our engineered delivery system presents a novel strategy for soft tissue reconstruction.
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