ArticleJournal of advanced research2026
Cellular and molecular mechanisms of nasolacrimal duct obstruction: New insights into CD4
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionNasolacrimal duct obstruction (NLDO) is a common ophthalmic condition characterized by epiphora and ocular discharge. Its etiology remains poorly understood, and treatment primarily relies on surgical intervention due to a lack of effective drugs.
objectivesTo characterize the single-cell transcriptional landscape of the nasolacrimal duct in patients with nasolacrimal duct obstruction (NLDO) and to elucidate the immunoregulatory mechanisms underlying the key fibrotic process driving disease progression.
methodsNasolacrimal duct tissues were obtained from 4 menopausal female patients by endoscopic dacryocystorhinostomy (DCR). Samples were collected from both the obstruction and para-blocked sites (Self-control of disease progression processes). Single-cell RNA sequencing was performed on the samples, and the cell composition and cell-cell interactions were analyzed. Subsequently, body fluid and tissue samples were obtained from 13 patients for histological and in vitro functional assays.
resultsTen major cell types were identified in 67,658 cells of the nasolacrimal duct. Intercellular communication analysis revealed the critical role of macrophage migration inhibitory factor (MIF) in the interaction between fibroblasts and immune cells. Histological analysis revealed significant inflammation and fibrosis in nasolacrimal duct obstruction. Mechanistically, CD4
conclusionThis study delineates the cellular transcriptomic profile of the nasolacrimal duct in NLDO patients and demonstrates that the MIF-centered immunoregulatory axis acts as a key driver of fibrotic obstruction, while plasma cells and CD8
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