Evidence map›Paper›PMID 41611045›Full record

ArticleNeuroImage2026

Detection of perivascular spaces at the gray-white matter interface using heavily T

Gael Saib, Zeynep H Demir, Paul A Taylor, S Lalith Talagala, Alan P Koretsky

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In one paragraph

Article in NeuroImage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gael SaibLaboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States. Electronic address: saibgh@nih.gov.
Zeynep H DemirLaboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States.
Paul A TaylorScientific and Statistical Computing Core, National Institute of Mental Health, National Institutes of Health, Maryland, United States.
S Lalith TalagalaNIH MRI Research Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States.
Alan P KoretskyLaboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States.

Funding

FUNCTIONAL IMAGING OF THE BRAIN AND HEARTZ01NS002989 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI KORETSKY, ALAN P. · 2000 to 2008
$5.0M
Intramural NIH HHS Z01 NS002989
6 · The paper itself

Abstract

backgroundThere is increasing interest in high-contrast cerebrospinal fluid (CSF) MRI for imaging perivascular spaces (PVSs). Dilated PVSs, associated with aging, dementia, and various other conditions, are readily detected within the white matter (WM), basal ganglia, and midbrain. While 7T MRI enables detection of smaller PVSs, cortical PVS burden has received limited attention despite its potential value for understanding neurological conditions. PURPOSE: To investigate the detectability of cortical PVS segments in healthy participants using heavily T MATERIALS AND

methodsA T

resultsSeventeen healthy volunteers (40±14 years) were scanned at 7T. Optimized TSE achieved a CSF-to-tissue CNR of ∼180:1, enabling detection of small PVSs throughout the brain and leukocortical segments. About 20% of WM PVSs contained a leukocortical segment. WM PVSs with a leukocortical segment represented 70% of the total PVS volume. PVS density in the cortex was ∼0.7% (∼6-fold lower than WM), with highest in the insula and lowest in the auditory cortex.

conclusionHigh-resolution CSF imaging using optimized 3D-TSE MRI at 7T allows detection and quantification of leukocortical PVS segments at the gray-white matter interface in healthy individuals. This study lays the groundwork for exploring regional PVS changes related to the cortex and their potential use in diagnosis or prognosis of neurological diseases.

Indexed as

Glymphatic SystemGray MatterMagnetic Resonance ImagingWhite MatterAdultFemaleHumansImaging, Three-DimensionalMaleMiddle AgedYoung Adult7TCortexGray-white matter interfaceHeavily T(2)-weighted MRILeukocorticalMRIPerivascular spacesUltra-high field

Identifiers

PMID41611045
PMCPMC13097009

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.