ArticleNeuropediatrics2026
Epilepsy and Neurodevelopment Outcomes 24 Months after Neonatal Hypoxic-Ischemic Encephalopathy and Predictive Factors of Post-neonatal Epilepsy.
Article in Neuropediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Timing-Dependent Effects of Dexamethasone in a Mouse Model of Neonatal Hypoxic-Ischemic Brain Injury: A Transcriptomic Analysis of Synaptic Signaling and Calcium Homeostasis.International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This retrospective, dual-center Italian study assessed the incidence, electroclinical characteristics, and risk factors for post-neonatal epilepsy among neonates with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH). The study aims to better define the long-term risk factors for developing epilepsy or neurodevelopmental issues.We included neonates with HIE who underwent TH. Neurological examination and general movements were assessed before and after TH. Amplified-integrated EEGs (aEEG) or polygraphic EEGs (pEEG) were performed within 6 hours of life; a pEEG was performed after TH (72 hours to 10 days) and at 3, 9 to 12, and 24 months, and then yearly. Brain MRI was conducted within 30 days. The 24-month developmental outcome was evaluated using Griffiths Mental Development Scales. The median follow-up duration was 48 months. Epilepsy was classified according to ILAE criteria.We enrolled 159 patients: 15 (9.4%) developed epilepsy. Nine (5.6%) had onset before 24 months; three of them developed infantile epileptic spasm syndrome (IESS). Seizure onset was after 24 months in 6/159 individuals (3.8%). At the last follow-up, all 15 patients had focal epilepsy. Global development was pathological in 11/15 (10/15 <2SD; 1/15 <1SD). Risk factors for post-neonatal epilepsy included: MRI lesions involving the basal ganglia and thalamus (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.