Evidence map›Paper›PMID 41610855›Full record

ReviewMolecular cell2026

Coordinating mRNA maturation: The U1 relay model.

Yoseop Yoon, Cailyx Quan, Lindsey V Soles, Yongsheng Shi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Design and discovery of 'tug-of-war' riboswitches.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yoseop YoonDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.
Cailyx QuanDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.
Lindsey V SolesDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Yongsheng ShiDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA; The Center for RNA Science and Therapeutics, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: yongshes@uci.edu.

Funding

mRNA alternative polyadenylation in B cell developmentR01AI170840 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Roger Sciammas, Yongsheng Shi · 2022 to 2026
$4.1M
Mechanisms and regulation of mRNA 3' processingR35GM149294 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Yongsheng Shi · 2023 to 2026
$2.1M
Decode polyadenylation in health and diseaseR01CA297834 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Yongsheng Shi · 2025 to 2026
$1.3M
NCI NIH HHS R01 CA297834NIAID NIH HHS R01 AI170840NIGMS NIH HHS R35 GM149294
6 · The paper itself

Abstract

mRNA maturation requires precise coordination among transcription, 5' capping, splicing, and 3' end formation. Recent biochemical, structural, and genomic studies demonstrate that these processes are tightly coupled through dynamic interactions among RNA polymerase II, the spliceosome, and cleavage-polyadenylation complexes. Here, we synthesize current mechanistic insights into how transcription elongation factors and RNA processing machineries communicate to ensure efficient and accurate transcript maturation. We propose a "U1 relay" model as a unified framework for understanding co-transcriptional splicing and 3' end formation. We further discuss how RNAs are sorted into nuclear retention/degradation or export pathways based on the RNA processing status. Importantly, RNA processing factors not only act downstream of transcription but also feed back to modulate transcriptional elongation, pausing, and termination, thereby reinforcing bidirectional coupling between RNA synthesis and processing.

Indexed as

RNA, MessengerRNA Processing, Post-TranscriptionalRNA SplicingActive Transport, Cell NucleusAnimalsHumansRNA Polymerase IIRNA StabilitySpliceosomesTranscription, GeneticRNA, MessengerRNA Polymerase IIcappingcleavage and polyadenylationdegradationexportnuclear retentionsplicing

Identifiers

PMID41610855
PMCPMC12866966

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.