Evidence map›Paper›PMID 41610841›Full record

ArticleNeuron2026

Spontaneous behavior is a succession of self-directed tasks.

Caleb Weinreb, Lakshanyaa Thamarai Kannan, Alia Newman-Boulle, Tim Sainburg, Winthrop F Gillis, Alex Plotnikoff, Sofia Makowska, Jonah E Pearl, Mohammed Abdal Monium Osman, Scott W Linderman and 1 more

Abstract read
In one paragraph

Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Solvable models of learning to pursue a moving target.Reinforcement learning journal · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Caleb WeinrebDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Lakshanyaa Thamarai KannanDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Alia Newman-BoulleDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Tim SainburgDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Winthrop F GillisDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Alex PlotnikoffDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Sofia MakowskaDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Jonah E PearlDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Mohammed Abdal Monium OsmanDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Scott W LindermanWu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA; Department of Statistics, Stanford University, Stanford, CA 94305, USA.
Sandeep Robert DattaDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: srdatta@hms.harvard.edu.

Funding

Towards a Unified Framework for Dopamine Signaling in the StriatumU19NS113201 · NINDS · HARVARD MEDICAL SCHOOL · PI DATTA, SANDEEP R · 2019 to 2023
$18.7M
Motion Sequencing for All: Pipelining, Distribution and Training to Enable Broad Adoption of a Next-Generation Platform for Behavioral and Neurobehavioral AnalysisU24NS109520 · NINDS · HARVARD MEDICAL SCHOOL · PI DATTA, SANDEEP R · 2019 to 2024
$2.3M
NINDS NIH HHS U19 NS113201NINDS NIH HHS U24 NS109520
6 · The paper itself

Abstract

Animals achieve high-level goals by sequencing low-level actions. This transformation is best understood in structured tasks that impose a specific mapping between goals and actions. However, it remains unclear whether spontaneous behavior is similarly organized in the service of identifiable goals or how it might be supported by brain regions responsible for goal-oriented behavior, such as the prefrontal cortex (PFC). Here, we show that low-level actions in freely exploring mice are hierarchically organized into seconds-long behavioral states that correspond to task-like programs of behavior. These persistent states structure neural activity in the PFC, which preferentially encodes the identity of states relative to low-level behavioral features and shapes which states are expressed in a given context. These findings argue that spontaneous behavior is organized as a succession of self-directed tasks and identify principles of neural control that are common to structured tasks and spontaneous exploration.

Indexed as

Behavior, AnimalExploratory BehaviorGoalsPrefrontal CortexAnimalsMaleMiceMice, Inbred C57BLcomputational ethologycomputational neuroethologyethologygoal-oriented behaviormachine learningmodelingmotivated behaviornatural behaviorprefrontal cortexspontaneous behavior

Identifiers

PMID41610841
PMCPMC13035047

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.