ArticleScience (New York, N.Y.)2026
Targeting modulated vascular smooth muscle cells in atherosclerosis via FAP-directed immunotherapy.
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
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Who cites it
17 citing papers in PubMed.
- Single-Cell Proteomics Uncovers Cell-Specific Proteins in Vascular Health and Marfan Syndrome Disease-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- FAP-Directed CAR-NKT Cells for Multi-Target Suppression of Atherosclerotic Progression.Circulation research · 2026Article
- Cell-Surface Signatures and Targets of Modulated Vascular Smooth Muscle Cells in Atherosclerosis: From State Identification to Precision Intervention.Journal of cardiovascular development and disease · 2026Review
- Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Therapeutic Target Mapping to Advance Drug Repurposing for Cardiovascular Disease: A Perspective from an Explanted Heart Biobank.Journal of personalized medicine · 2026Review
- Vascular Smooth Muscle Cell Plasticity in Atherosclerosis: Mechanisms, Recent Advances, and Therapeutic Implications.Reviews in cardiovascular medicine · 2026Review
- Smooth Muscle Cell Cytoglobin is a Negative Regulator of Atherosclerotic Fibrous Cap Development.bioRxiv : the preprint server for biology · 2026Article
- Non-canonical ceRNA-independent mechanism of the lncRNA-H19/miR-212-5p axis targeting KLF4 in Hcy-triggered VSMCs dysfunction and atherogenesis.Scientific reports · 2026Article
- Bispecific antibody engineered extracellular vesicles redirect T cells to prevent postoperative epidural fibrosis.Nature communications · 2026Article
- Research Progress on the Molecular Mechanism of LRP1 and TGFβ-PDGFRβ Signaling Network in Atherosclerosis and Vascular Remodeling.International journal of molecular sciences · 2026Review
- Multimodal atlas of human atherosclerosis links granular vascular cell states to coronary artery disease risk.medRxiv : the preprint server for health sciences · 2026Article
- Editing the Plaque: Immunotherapy Targeting Pathogenic Smooth Muscle Cells in Atherosclerosis.JACC. Basic to translational science · 2026Article
- SIRT1 in Atherosclerosis: Integrative Control of Vascular Metabolism, Inflammation and Aging.International journal of molecular sciences · 2026Review
- Fibroblast activation protein inhibitor radiotheranostics for imaging activated tumor stroma and guiding radionuclide therapy.Frontiers in oncology · 2026Review
- A single-cell and spatial atlas of plaque macrophage states in human atherosclerosis.Frontiers in immunology · 2026Review
- Pharmacological considerations for next-generation protein therapeutics in cardiovascular disease.The Journal of pharmacology and experimental therapeutics · 2025Review
- Cellular and Transcriptional Landscape of Human Hypoplastic Left Heart Syndrome.Research square · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors.
Junedh M AmruteCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-6851-0168
In-Hyuk JungCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-9469-9590
Tracy YamawakiAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.ORCID 0000-0002-7716-5650
Wen-Ling LinAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.ORCID 0009-0005-5986-9629
Andrea BredemeyerCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0003-2970-5998
Johanna DiekmannDepartment of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, Germany.ORCID 0000-0002-7008-3601
Sikander HayatInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Templergraben 55, Aachen, Germany.ORCID 0000-0001-5919-8371
Xianglong ZhangAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.
Devin L WakefieldAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.ORCID 0000-0002-0914-0558
Xin LuoAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.ORCID 0000-0002-2317-7816
Sidrah MaryamInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Templergraben 55, Aachen, Germany.
Gyu Seong HeoMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0001-6200-4742
Steven YangCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-5168-4858
Chang Jie Mick LeeCardiovascular Metabolic Disease Translational Research Programme, National University Health System, Centre for Translational Medicine, 14 Medical Drive, Singapore, Singapore.ORCID 0000-0001-6673-9391
Chen WangAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.ORCID 0009-0000-1913-1535
Caroline ChouCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0009-0007-2396-088X
Christoph KuppeDepartment of Nephrology, RWTH Aachen, Medical Faculty, Templergraben 55, Aachen, Germany.ORCID 0000-0003-4597-9833
Kevin D CookAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.ORCID 0000-0003-3079-4174
Atilla KovacsCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Vishnu ChintalgattuAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.ORCID 0000-0002-4766-5400
Danielle PruittAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.ORCID 0009-0002-8277-8467
Jose BarredaAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.ORCID 0009-0003-9950-3029
Nathan O StitzielCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-4963-8211
Paul ChengDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3429-2702
Yongjian LiuMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-1118-1535
Rafael KramannInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Templergraben 55, Aachen, Germany.ORCID 0000-0003-4048-6351
Daniel KreiselDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-7711-8651
Roger S-Y FooCardiovascular Metabolic Disease Translational Research Programme, National University Health System, Centre for Translational Medicine, 14 Medical Drive, Singapore, Singapore.ORCID 0000-0002-8079-4618
Ingrid C RulifsonAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.ORCID 0000-0003-3251-3989
Scott MartinAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.ORCID 0000-0001-5685-9787
David GrunertAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.
Melissa ThomasAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.ORCID 0000-0001-6719-9307
Jixin CuiAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.
Thomas QuertermousDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-7645-9067
Frank M BengelDepartment of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, Germany.ORCID 0000-0003-4529-7963
Simon JacksonAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.
Chi-Ming LiAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.ORCID 0000-0002-2740-5652
Brandon AsonAmgen, 750 Gateway Blvd, South San Francisco, CA, USA.
Kory J LavineCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0003-1948-9945
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI Shawn Shafer · 2001 to 2026
$128.0MTraining/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Robert J. Gropler · 2018 to 2026
$12.7MWashington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Deborah J Lenschow, Christine T. Pham · 2018 to 2026
$7.6MTargeted Molecular Probes for Atherosclerosis Imaging and TherapyR35HL145212 · NHLBI · WASHINGTON UNIVERSITY · PI LIU, YONGJIAN · 2019 to 2025
$5.1MSpecification and Function of Tissue Resident and Recruited Macrophages in Cardiac Remodeling and Heart FailureR35HL161185 · NHLBI · WASHINGTON UNIVERSITY · PI Kory J. Lavine · 2022 to 2026
$4.3MPET Detection of CCR2 in Human AtherosclerosisR01HL150891 · NHLBI · WASHINGTON UNIVERSITY · PI GROPLER, ROBERT J., WOODARD, PAMELA K · 2020 to 2024
$3.7MThe Role of Donor Innate Immune Responses in Regulating Alloimmunity after Heart TransplantationR01HL151078 · NHLBI · WASHINGTON UNIVERSITY · PI KREISEL, DANIEL, LAVINE, KORY J. · 2020 to 2023
$2.6MMACROPHAGE HETEROGENEITY IN HEART FAILURE PROGRESSION AND CARDIAC RECOVERYR01HL138466 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2017 to 2021
$1.9MMACROPHAGE ONTOGENY SHIFTS IN ISCHEMIC HEART DISEASER01HL139714 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2018 to 2021
$1.5MNCI NIH HHS P30 CA091842NHLBI NIH HHS R01 HL138466NHLBI NIH HHS R01 HL139714NHLBI NIH HHS R01 HL150891NHLBI NIH HHS R01 HL151078NHLBI NIH HHS R35 HL145212NHLBI NIH HHS R35 HL161185NIAMS NIH HHS P30 AR073752NIBIB NIH HHS P41 EB025815
Abstract
Vascular smooth muscle cell (VSMC) diversification drives atherosclerotic coronary artery disease (CAD). Mechanisms governing these cell state transitions remain unclear. We applied multiomic single-cell profiling, epitope mapping, and spatial transcriptomics across 27 human coronary arteries, identifying fibroblast activation protein (FAP) as a marker of modulated VSMCs. Lineage tracing in mice indicated that FAP
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.