ArticleWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
An Autologous, Vascularized and Immunocompetent Tissue Engineered Skin to Highlight Inter-Individual Variability to Better Understand the Human Wound Healing.
Article in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Skin innervation and itsFrontiers in cellular neuroscience · 2026Review
- An Autologous, Vascularized and Immunocompetent Tissue Engineered Skin to Highlight Inter-Individual Variability to Better Understand the Human Wound Healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
In vitro tissue-engineered skin models are valuable tools for dermatological research. Yet, they often fail to reproduce the complex interactions among vascular, immune, and cutaneous cells during the wound healing process. In addition, inter-individual variability response remains poorly understood, limiting our knowledge of the genetic and environmental factors that influence wound healing. This study presents a 3D autologous, vascularised, and immunocompetent Tissue Engineered Skin model (aviTES), generated using cells from the same donor to study the wound healing process. The aviTES models were injured using a 2 mm punch biopsy, and wound closure was macroscopically monitored for 7 days in the absence of any stimuli. The re-epithelialisation rate was highly reproducible within the same donor. However, wound closure differed between healthy donors (five distinct donors), highlighting individual variability. Indeed, in most cases, complete re-epithelialisation was observed within 2-4 days, but one did not close completely after 7 days. Immunofluorescence analysis revealed lymphocytes (CD45+/CD3+) migration for all donors, but no migration of CD206-positive cells or neo-angiogenesis into the wound sites. By contrast, platelet lysate treatment promoted epidermal cell migration, capillary organisation/neo-angiogenesis, and altered collagen and MMP secretion at levels that were specific to each donor, highlighting donor-specific responses to treatment. This innovative autologous skin model reproduced several key features of the human wound healing process and may represent a new tool for studying wound healing process and inter-individual variability, paving the way for advances in personalised medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.