Evidence map›Paper›PMID 41609934›Full record

ArticleJournal of dental education2026

Experimental Pain Research as an Effective Active Learning Method for Pain Education.

Soraya Salmanzadeh Ardestani, Isadora Alves Lorenzo, Rhayane da Conceição Monteiro, Ana Clara Hecker de Carvalho, Leonardo Rigoldi Bonjardim, Fernando Gustavo Exposto, Fernanda Klein Marcondes, Yuri Martins Costa

Abstract read
In one paragraph

Article in Journal of dental education, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Soraya Salmanzadeh ArdestaniDepartment of Periodontology and Prosthodontics, Faculdade de Odontologia de Piracicaba (FOP), Universidade Estadual de Campinas (UNICAMP), São Paulo, Brazil.
Isadora Alves LorenzoDepartment of Biosciences, Faculdade de Odontologia de Piracicaba (FOP), Universidade Estadual de Campinas (UNICAMP), São Paulo, Brazil.
Rhayane da Conceição MonteiroDepartment of Biosciences, Faculdade de Odontologia de Piracicaba (FOP), Universidade Estadual de Campinas (UNICAMP), São Paulo, Brazil.
Ana Clara Hecker de CarvalhoDepartment of Biosciences, Faculdade de Odontologia de Piracicaba (FOP), Universidade Estadual de Campinas (UNICAMP), São Paulo, Brazil.
Leonardo Rigoldi BonjardimDepartment of Biological Sciences, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil.
Fernando Gustavo ExpostoDepartment of Dentistry and Oral Health, Section for Orofacial Pain and Jaw Function Aarhus University, Aarhus, Denmark.
Fernanda Klein MarcondesDepartment of Biosciences, Faculdade de Odontologia de Piracicaba (FOP), Universidade Estadual de Campinas (UNICAMP), São Paulo, Brazil.
Yuri Martins CostaDepartment of Biosciences, Faculdade de Odontologia de Piracicaba (FOP), Universidade Estadual de Campinas (UNICAMP), São Paulo, Brazil.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de São Paulo 2019/15826-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2025/10791-2
6 · The paper itself

Abstract

purposeThis cohort study evaluated the perception of undergraduate dental students regarding the effectiveness of a practical learning activity involving experimental pain research.

methodsSeventy-six first-semester students participated in a 40-min activity consisting of four stages: demonstration, baseline assessment, intervention, and post-intervention. Pain and unpleasantness intensities were measured using mechanical stimuli applied to the face and forearm, assessed with a 0-100 mm visual analog scale. The intervention involved visual and verbal cues suggesting analgesia on one side and hyperalgesia on the other, followed by a 10-min application of topical anesthetic cream on both sides. Students completed a questionnaire rating the activity's effectiveness on a 0-10 numeric rating scale and took a theoretical exam. ANOVA, Wilcoxon test, and Spearman correlation were applied to data (p < 0.050).

resultsThe mean (SD) effectiveness rating for facilitating learning was 8.75 (1.26), and for increasing interest and curiosity in the subject, it was 8.89 (1.18). There was no significant relationship between students' perceptions and their theoretical exam performance (p > 0.050). There was a reduction in pain and unpleasantness with the suggestion of analgesia, -0.70 (14.70) and -2.94 (16.23), and an increase in pain and unpleasantness with the suggestion of hyperalgesia, 5.85 (12.85) and 1.70 (14.74) (p < 0.001).

conclusionWe conclude that it is possible to replicate results from experimental pain research in a teaching environment. Thus, incorporating experiments as a teaching method is valuable and effective for pain education. SIGNIFICANCE: This study presents a novel approach to pain education. It was demonstrated that rigorous research methodologies can be effectively integrated into the educational setting.

Indexed as

Education, DentalPainPain ManagementProblem-Based LearningCohort StudiesFemaleHumansMalePain MeasurementStudents, Dentalexperimental painlearningnocebo effectpain educationteaching

Identifiers

PMID41609934
PMCPMC13568962

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.