Evidence map›Paper›PMID 41609908›Full record

ArticleApplied biochemistry and biotechnology2026

Plasticization of an Ageratum Conyzoides Natural Extract in Crosslinked Hydrogel: a Promising Material for Combating Wound Infection.

Riddhi Kantesaria, Yimar Bagra, Payal Varma, Himanshu Sekhar Panda

Abstract read
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Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Riddhi KantesariaDepartment of Metallurgical and Materials Engineering, Defence Institute of Advanced Technology, Pune, 411025, India.
Yimar BagraDepartment of Metallurgical and Materials Engineering, Defence Institute of Advanced Technology, Pune, 411025, India.
Payal VarmaDepartment of Metallurgical and Materials Engineering, Defence Institute of Advanced Technology, Pune, 411025, India.
Himanshu Sekhar PandaDepartment of Metallurgical and Materials Engineering, Defence Institute of Advanced Technology, Pune, 411025, India. himanshusp@diat.ac.in.ORCID http://orcid.org/0000-0003-1353-3714

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of advanced wound dressings that combine structural stability with therapeutic functionality is vital for improving the wound healing process. In this study, a polyvinyl alcohol (PVA) hydrogel crosslinked with citric acid (CA) was fabricated and loaded with phytochemicals extracted from Ageratum conyzoides (ACE-CA/PVA). The biodegradable, biocompatible hydrogel was fabricated via esterification and systematically analysed to confirm successful crosslinking, structural integrity, surface morphology, and thermal behaviour. The ACE-CA/PVA hydrogel exhibited pH-responsive swelling, favourable water retention, and a biphasic drug release profile. Antimicrobial studies demonstrated enhanced inhibition of Staphylococcus aureus, Escherichia coli, and Aspergillus niger compared to blank hydrogels, while cytotoxicity assays confirmed good biocompatibility with L929 fibroblast cells. Thermal analyses indicated improved char yield and flexibility, while morphological evaluation revealed hierarchical porosity conducive to controlled release and tissue integration. Collectively, the results highlight ACE-CA/PVA hydrogel as a promising dual-function wound dressing that provides both a moist healing environment and plant-derived bioactive therapeutic benefits. This work signifies the potential of integrating phytochemicals with polymeric hydrogels for next-generation clinical application in acute and chronic wound management.

Indexed as

AgeratumAnti-Bacterial AgentsHydrogelsPlant ExtractsWound InfectionAnimalsAspergillus nigerCell LineCitric AcidEscherichia coliMicePolyvinyl AlcoholStaphylococcus aureusAnti-Bacterial AgentsCitric AcidHydrogelsPlant ExtractsPolyvinyl AlcoholAgeratum conyzoidesAntimicrobial activityCitric acid (CA)CytotoxicityHydrogelPolyvinyl alcohol (PVA)Wound healing

Identifiers

PMID41609908

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.