Evidence map›Paper›PMID 41609767›Full record

ArticleEuropean radiology2026

Mediation of ghost infarct core on prognosis by venous outflow and net water uptake after stroke thrombectomy.

Yingzi Li, Zhiyi Zong, Chentao Wang, Kechun Chen, Da Liang, Puzhi Wang, Chongke Zhong, Meili Zhou, Chun-Feng Liu, Weidong Hu and 1 more

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Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yingzi Li *Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Zhiyi Zong *Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Chentao Wang *Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Kechun ChenDepartment of Neurology, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang First People's Hospital, Suzhou, China.
Da LiangDepartment of Neurology, The First People's Hospital of Kunshan, Suzhou, China.
Puzhi WangDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Chongke ZhongDepartment of Epidemiology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.
Meili ZhouDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Chun-Feng LiuDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Weidong HuDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China. weidonghusz@163.com.
Huihui LiuDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China. lucy_huihui@126.com.ORCID http://orcid.org/0000-0002-4761-2800

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 82071310Innovative Research Group Project of the National Natural Science Foundation of China 82571501project of China International Medical Foundation 2022-N-01-26Suzhou Gusu Medical Youth Talent GSWS2022031
6 · The paper itself

Abstract

objectivesThis study aimed to investigate whether venous outflow (VO) and net water uptake (NWU) mediate the relationship between the ghost infarct core (GIC) and clinical outcomes in patients with acute ischemic stroke (AIS) who underwent endovascular treatment (EVT). MATERIALS AND

methodsAIS patients who underwent Computed Tomography Perfusion (CTP) imaging and EVT at three tertiary hospitals between January 2019 and March 2024 were included. GIC was defined as a difference exceeding 10 mL between the initial CTP-derived core volume and the final infarct volume. Multiple mediation analyses were conducted to assess the mediating roles of VO and NWU in the relationship between GIC and a 90-day favorable functional outcome, defined as a modified Rankin Scale of 0-2.

resultsAmong 313 included patients, 48 (15.3%) had GIC. Multivariable regression analysis revealed that GIC significantly increased the likelihood of a favorable outcome (p < 0.001). Multiple mediation analyses revealed that GIC was associated with both favorable VO (β = 0.34, 95% CI 0.21-0.48, p < 0.001) and lower baseline NWU (β = -1.71, 95% CI -2.43 to -1.08, p < 0.001). Favorable VO and lower NWU mediated 44.5% and 14.5% of the total effect of GIC on favorable outcome, respectively. Analyses based on an alternative causal ordering yielded consistent results.

conclusionGIC was significantly associated with favorable functional outcomes at 90 days in AIS patients following EVT. Favorable VO and reduced baseline NWU mediated a significant proportion (~ 60%) of the overall effect of GIC on a favorable functional outcome. KEY POINTS: Question It remains unclear whether venous outflow (VO) and net water uptake (NWU) mediate the effect of ghost infarct core (GIC) on clinical outcomes in acute ischemic stroke (AIS) patients. Findings The association between GIC and 90-day favorable functional outcomes in AIS patients undergoing endovascular treatment (EVT) was partially mediated by favorable VO and baseline NWU. Clinical relevance GIC was significantly associated with a 90-day favorable functional outcome in AIS patients undergoing EVT. Joint evaluation of VO status and baseline NWU may help optimize selection for EVT in AIS patients and improve clinical outcomes.

Indexed as

Ischemic StrokeStrokeThrombectomyTomography, X-Ray ComputedAgedEndovascular ProceduresFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesTreatment OutcomeWaterWaterCerebral infarctionIschemic strokeMediation analysisNeuroimagingThrombectomy

Identifiers

PMID41609767

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.