Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2026
Low-energy cooling strategies modulate biomarkers of kidney injury risk in older adults exposed to very hot and dry heat.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Acute kidney injury (AKI) contributes to excess hospital admissions observed during heatwaves. We tested the hypothesis that water spray and fan use would modulate biomarkers of AKI risk in older adults exposed to 3 h of very hot and dry heat. On each of 3 days (randomized), older adults (12 males/8 females; 66-84 yr) were exposed to 3 h of heating (47°C, 15% relative humidity) with no cooling intervention (control), water spray, or fan use. We assessed core temperature, fluid loss, biomarkers of AKI risk (AKIRISK score), and kidney function (plasma creatinine and cystatin C). The increase in core temperature was 1.3 ± 0.5°C (means ± SD) in control, 1.0 ± 0.2°C in water spray, and 1.9 ± 0.7°C in the fan trial. Fluid loss was 0.9 ± 0.2% in control, 0.4 ± 0.2% in water spray, and 1.5 ± 0.4% in fan. Compared with control, the AKIRISK score at end-heating was -0.18 [95% CI: -0.35, -0.02] lower in water spray (
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