Evidence map›Paper›PMID 41609627›Full record

ArticleJournal of chemical information and modeling2026

Unravelling the Role Played by Non-covalent Interactions in the Action Mechanism of PCDDs within Cells.

Lorena Ruano, Álvaro Pérez-Barcia, Vito F Palmisano, Juan J Nogueira, Marcos Mandado, Nicolás Ramos-Berdullas

Abstract read
In one paragraph

Article in Journal of chemical information and modeling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lorena RuanoDepartment of Chemistry, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
Álvaro Pérez-BarciaDepartment of Physical Chemistry, University of Vigo, Lagoas-Marcosende s n, ES-36310 Vigo, Galicia, Spain.
Vito F PalmisanoDepartment of Chemistry, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
Juan J NogueiraDepartment of Chemistry, Universidad Autónoma de Madrid, 28049 Madrid, Spain.ORCID 0000-0001-7419-5670
Marcos MandadoDepartment of Physical Chemistry, University of Vigo, Lagoas-Marcosende s n, ES-36310 Vigo, Galicia, Spain.ORCID 0000-0001-9688-2658
Nicolás Ramos-BerdullasDepartment of Physical Chemistry, University of Vigo, Lagoas-Marcosende s n, ES-36310 Vigo, Galicia, Spain.ORCID 0000-0001-5497-3738

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates biological signals and regulates diverse cellular functions. Of particular concern are the effects triggered by dioxins and dioxin-like compounds (DLCs), whose toxicological outcomes arise through both canonical and noncanonical pathways, leading to the designation of AhR as the "dioxin receptor". However, conventional risk assessment approaches based on toxic equivalency factors (TEFs), which primarily reflect the capacity of these compounds to bind and activate AhR, do not fully account for critical aspects such as environmental concentration and bioavailability, potentially underestimating their true impact. In this work, we present a comparative analysis of polychlorinated dibenzo-

Indexed as

Polychlorinated DibenzodioxinsReceptors, Aryl HydrocarbonLigandsMolecular Dynamics SimulationQuantum MechanicsQuantum TheoryLigandsPolychlorinated DibenzodioxinsReceptors, Aryl Hydrocarbon

Identifiers

PMID41609627
PMCPMC12892313

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.