Evidence map›Paper›PMID 41609617›Full record

ArticleAnalytical chemistry2026

Automated Enrichment of DNA Biomarkers from Large-Volume Samples: Detection of

Alie M Bogusch, Evan H Benke, Jordan T Ruit, Abraham A Akinladenu, David J Boegner, Ian M White

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alie M BoguschFischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.
Evan H BenkeFischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.
Jordan T RuitFischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.
Abraham A AkinladenuFischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.
David J BoegnerFischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.ORCID 0000-0002-8900-5208
Ian M WhiteFischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.ORCID 0000-0003-4426-9311

Funding

A rapid, automated system for bacteria profiling of intra-abdominal infectionsR01AI153564 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI DEVOE, DON L, WHITE, IAN M · 2021 to 2025
$2.7M
NIAID NIH HHS R01 AI153564
6 · The paper itself

Abstract

Liquid biopsies enable rapid and noninvasive analysis for disease biomarkers. However, in the early stages of a disease, biomarkers are often present in extremely dilute concentrations, making them difficult to isolate and quantify. We have developed an Automated Magnetically and Thermally Induced Conical Separator (Auto-MATICS), which enables purification and enrichment of trace biomarkers from large volume biological samples (up to 15 mL) using magnetic beads and thermally responsive alkane partitions (TRAPs). Here, we quantify the enrichment capabilities of the Auto-MATICS and demonstrate a diagnostic application by detecting fragmented genomic DNA from

Indexed as

Borrelia burgdorferiCell-Free Nucleic AcidsDNA, BacterialLyme DiseaseAutomationBiomarkersHumansBiomarkersCell-Free Nucleic AcidsDNA, Bacterial

Identifiers

PMID41609617
PMCPMC13401756

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.