Evidence map›Paper›PMID 41609498›Full record

ArticleThe Journal of physiology2026

Selective RyR2 inhibition reduces arrhythmia susceptibility in human cardiac slices.

Micah K Madrid, Katy A Trampel, Batool Salman, Sharon A George, Abigail N Smith, Jeffrey N Johnston, Tatiana Efimova, Bjorn Knollmann, Igor R Efimov

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Micah K MadridDepartment of Biomedical Engineering, Northwestern University, Chicago, IL, USA.
Katy A TrampelDepartment of Biomedical Engineering, Northwestern University, Chicago, IL, USA.
Batool SalmanDepartment of Biomedical Engineering, Northwestern University, Chicago, IL, USA.ORCID 0009-0005-0666-7513
Sharon A GeorgeDepartment of Biomedical Engineering, Northwestern University, Chicago, IL, USA.
Abigail N SmithDepartment of Chemistry, Vanderbilt University, Nashville, TN.
Jeffrey N JohnstonDepartment of Chemistry, Vanderbilt University, Nashville, TN.
Tatiana EfimovaDepartment of Biomedical Engineering, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-9869-1545
Bjorn KnollmannVanderbilt Center for Arrhythmia Research and Therapeutics, Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0003-4956-9735
Igor R EfimovDepartment of Biomedical Engineering, Northwestern University, Chicago, IL, USA.

Funding

Development of Mirror-Image Natural Products as Antiarrhythmic TherapeuticsR01HL181098 · NHLBI · VANDERBILT UNIVERSITY · PI Jeffrey Nicholas Johnston · 2025 to 2026
$1.5M
American Heart Association-American Stroke Association AHA_19SFRN34830033NHLBI NIH HHS R01 HL181098
6 · The paper itself

Abstract

Ryanodine receptor 2 (RyR2) hyperactivity is frequently observed in structural heart disease (SHD), commonly caused by ischemic heart disease. This aberrant Ca

Indexed as

Anti-Arrhythmia AgentsArrhythmias, CardiacCalcium Channel BlockersRyanodine Receptor Calcium Release ChannelAgedFemaleHumansIsoproterenolMaleMiddle AgedAnti-Arrhythmia AgentsCalcium Channel BlockersIsoproterenolRyanodine Receptor Calcium Release ChannelRyR2 protein, humanent‐verticilideryanodine receptor 2RyR2structural heart disease

Identifiers

PMID41609498
PMCPMC12953022

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.