Evidence map›Paper›PMID 41609390›Full record

ArticleMolecular carcinogenesis2026

A Genome-Wide Association Study of Colorectal Cancer Mortality Outcomes Among Individuals of African and Admixture Ancestry.

Thomas Lawler, Jirong Long, Rene Welch, Irene Ong, Oluwatoyosi Ogunmuyiwa, Rida A Khatri, Martha Shrubsole, Shaneda Warren Andersen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular carcinogenesis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thomas LawlerSchool of Medicine and Public Health, Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jirong LongDepartment of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Nashville, Tennessee, USA.
Rene WelchSchool of Medicine and Public Health, Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Irene OngSchool of Medicine and Public Health, Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-9353-6941
Oluwatoyosi OgunmuyiwaDepartment of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Rida A KhatriDepartment of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Martha ShrubsoleDepartment of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Nashville, Tennessee, USA.
Shaneda Warren AndersenSchool of Medicine and Public Health, Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Southern Community Cohort StudyU01CA202979 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., SHRUBSOLE, MARTHA J. · 2016 to 2025
$22.0M
Understanding the Contribution of Colorectal Cancer Tumor Characteristics to Disparities in Colorectal Cancer SurvivalR01CA255318 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Shaneda Warren Andersen · 2021 to 2026
$2.8M
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA255318NCI NIH HHS U01 CA202979The American Recovery and Reinvestment Act 3R01 CA092447-08S1University of Wisconsin-Madison, Office of Vice Chancellor for Research and Graduate Education with funding from the Wisconsin Alumni Research FoundationVanderbilt-Ingram Cancer Center P30CA68485
6 · The paper itself

Abstract

African Americans have the highest colorectal cancer (CRC) mortality rates in the United States. We performed the first genome-wide association study (GWAS) of overall and CRC-specific mortality among African Americans with incident CRC to identify genetic contributors to CRC outcomes. Participants enrolled in the Southern Community Cohort Study in 2002-2009; incident CRC and mortality were identified via state cancer registries and the National Death Index. SNPs were genotyped across the genome via Illumina platforms and imputed using the Michigan Imputation Server with Minimac4. Associations with mortality were estimated as hazard ratios (HRs) with 95% confidence intervals (CIs) using Cox proportional hazards models, adjusted for age, sex, stage, and five principal components for ancestry. In total, 500 Black-identifying participants were analyzed, including 316 deaths and 184 CRC-specific deaths. Two novel loci in linkage disequilibrium (r

Indexed as

Black or African AmericanColorectal NeoplasmsGenome-Wide Association StudyAgedFemaleGenetic Predisposition to DiseaseHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotideUnited StatesBlack peoplecolorectal neoplasmshealth status disparitiesrace factors

Identifiers

PMID41609390
PMCPMC12973162

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.