Evidence map›Paper›PMID 41609360›Full record

ArticleClinical and experimental dental research2026

The Association Between Serum Immunoglobulin G Titers Against Porphyromonas gingivalis and Chronic Kidney Disease in Patients With Rheumatoid Arthritis and Periodontitis: A Retrospective Cohort Study.

Tetsuo Kobayashi, Satoshi Ito, Noriko Sugita, Akira Murasawa, Hajime Ishikawa, Koichi Tabeta

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In one paragraph

Article in Clinical and experimental dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tetsuo KobayashiDepartment of Dentistry, National Hospital Organization Niigata National Hospital, Kashiwazaki, Japan.ORCID 0000-0001-8250-4234
Satoshi ItoDepartment of Rheumatology, Niigata Rheumatic Center, Shibata, Japan.
Noriko SugitaDivision of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Akira MurasawaDepartment of Rheumatology, Niigata Rheumatic Center, Shibata, Japan.
Hajime IshikawaDepartment of Rheumatology, Niigata Rheumatic Center, Shibata, Japan.
Koichi TabetaDivision of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Funding

KAKENHI Grant-in Aid for Scientific Research 21K09891KAKENHI Grant-in Aid for Scientific Research 24K12928
6 · The paper itself

Abstract

objectivesChronic kidney disease (CKD) is relatively common in patients with rheumatoid arthritis (RA). Periodontitis and periodontopathic Porphyromonas gingivalis are risk factors for CKD. However, the association of serum immunity to P. gingivalis and its peptidylarginine deiminase (PPAD), as well as periodontitis severity, with CKD in relation to RA has not been elucidated. The present study evaluated whether or not serum immunoglobulin G (IgG) titers against P. gingivalis and PPAD and periodontitis severity are associated with CKD in patients with RA and periodontitis.

methodsDemographic, comorbidity, rheumatologic, and periodontal data were collected from 127 patients with RA and periodontitis in a retrospective cohort study. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m

resultsTwenty patients showed an eGFR < 60 mL/min/1.73 m

conclusionsThese results suggest that serum IgG titers against P. gingivalis, but not against PPAD, are associated with CKD in patients with RA and periodontitis.

Indexed as

Antibodies, BacterialArthritis, RheumatoidImmunoglobulin GPeriodontitisPorphyromonas gingivalisRenal Insufficiency, ChronicAdultAgedFemaleGlomerular Filtration RateHumansMaleMiddle AgedProtein-Arginine DeiminasesRetrospective StudiesRisk FactorsAntibodies, BacterialImmunoglobulin GProtein-Arginine Deiminaseschronic kidney diseaseperiodontitisPorphyromonas gingivalisrheumatoid arthritis

Identifiers

PMID41609360
PMCPMC12853967

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.