Evidence map›Paper›PMID 41609282›Full record

ArticleJACC. Advances2026

Childhood Maltreatment and Cardiovascular Health: Role of Sex and Life's Essential 8 in the U.K. Biobank.

Bikram Bucha, Yuanjing Li, Örjan Ekblom, Victoria Blom, Xin Xia, Hui-Xin Wang, Rui Wang

Abstract read
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In one paragraph

Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bikram BuchaDepartment of Physical Activity and Health, the Swedish School of Sport and Health Science, GIH, Stockholm, Sweden. Electronic address: Bikram.bucha@gih.se.
Yuanjing LiDepartment of Physical Activity and Health, the Swedish School of Sport and Health Science, GIH, Stockholm, Sweden.
Örjan EkblomDepartment of Physical Activity and Health, the Swedish School of Sport and Health Science, GIH, Stockholm, Sweden; Division of Nursing, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Victoria BlomDepartment of Physical Activity and Health, the Swedish School of Sport and Health Science, GIH, Stockholm, Sweden.
Xin XiaDivision of Neurogeriatrics, Department of NVS, Karolinska Institutet, Stockholm, Sweden.
Hui-Xin WangStress Research Institute, Department of Psychology, Stockholm University, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Rui WangDepartment of Physical Activity and Health, the Swedish School of Sport and Health Science, GIH, Stockholm, Sweden; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. Electronic address: rui.wang@gih.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChildhood maltreatment (CM) may increase cardiovascular disease (CVD) risk through behavioral and health pathways; while maintaining cardiovascular health, Life's Essential 8 (LE8) may modify this association.

objectivesThe objective of the study was to examine the link between CM and LE8, and to quantify the potential moderating role of LE8 scores in CM-related CVD risk for men and women.

methodsWe included 153,399 participants aged ≥40 years at baseline in the U.K. Biobank. CM was assessed using the online Childhood Trauma Screener. LE8 scores were calculated based on 8 behavioral and health factors. Incident CVDs were identified through linkage to patient and death registers up to 2022. Linear and Cox regressions were used.

resultsAll CM events were significantly associated with lower LE8 scores in both sexes, with stronger associations observed with increasing cumulative CM exposure (β

conclusionsThe impact of early-life adversities can be offset by adopting good lifelong lifestyle practices. This study underscores the need to identify individuals, particularly women, with experiences of cumulative CM events and support interventions to improve their opportunity, capability, and motivation to enhance LE8.

Indexed as

cardiovascular diseasecardiovascular healthchildhood adversitychildhood maltreatmentLife’s essential 8

Identifiers

PMID41609282
PMCPMC12869877

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.