Evidence map›Paper›PMID 41609003›Full record

ArticleThe Cochrane database of systematic reviews2026

Diagnostic tests for autism spectrum disorder (ASD) in preschool children.

Amanda Brignell, Kris Chan, Tayla Chellew, Chathuri Vihanga Maddumahewa, Nicole Wong, Lotty Hooft, Mohammed Alshawsh, Katrina Williams

Abstract read
In one paragraph

Article in The Cochrane database of systematic reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amanda BrignellDepartment of Paediatrics, Monash University, Melbourne, Australia.
Kris ChanDepartment of Paediatrics, Monash University, Melbourne, Australia.
Tayla ChellewDepartment of Paediatrics, Monash University, Melbourne, Australia.
Chathuri Vihanga MaddumahewaDepartment of Paediatrics, Monash University, Melbourne, Australia.
Nicole WongDepartment of Paediatrics, Monash University, Melbourne, Australia.
Lotty HooftJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.
Mohammed AlshawshDepartment of Paediatrics, Monash University, Melbourne, Australia.ORCID 0000-0001-8342-5183
Katrina WilliamsDepartment of Paediatrics, Monash University, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis is a protocol for a Cochrane Review (diagnostic). The objectives are as follows: Primary objectives To evaluate the diagnostic accuracy of widely used ASD diagnostic tools (specifically CARS, GARS, ADOS, ADI-R, DISCO, 3di) in preschool children, compared with multidisciplinary team clinical judgement. We aim to: summarise sensitivity, specificity, and other accuracy measures for each ASD diagnostic tool; and for studies that compare two or more tools within the same study, describe and compare their diagnostic accuracy. To identify if any combination of diagnostic tools has greater diagnostic test accuracy than each single tool. We aim to: describe combined diagnostic test accuracy within a single study; and compare combined diagnostic test accuracy to individual test accuracy from primary objective 1a. Secondary objectives To assess whether there is different diagnostic test accuracy for subgroups such as intellectual disability, language level, setting, prospective versus retrospective, DSM diagnostic classification and specific ages (within the preschool age range).

Indexed as

Autism Spectrum DisorderDiagnostic Tests, RoutineChild, PreschoolHumansSensitivity and Specificity

Identifiers

PMID41609003
PMCPMC12853414

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.