SynthesisJournal of pediatric gastroenterology and nutrition2026
Serum predictors of native liver survival post-Kasai: Systematic review and meta-analysis.
Synthesis in Journal of pediatric gastroenterology and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Serum predictors of native liver survival post-Kasai: Systematic review and meta-analysis.Journal of pediatric gastroenterology and nutrition · 2026Pooled it
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesAfter hepatoportoenterostomy (HPE), a minority of biliary atresia (BA) patients reach adolescence without liver transplantation. Several serum markers have been suggested to better predict post-HPE outcomes in BA patients. We aimed to identify serum predictors of native liver survival (NLS) in post-HPE BA patients.
methodsWe searched PubMed, MEDLINE, SCOPUS, and EMBASE databases to identify publications from 1946 through December 2023. Studies included reported serum values as prognostic factors for BA after HPE, specifically total bilirubin (TB), alanine transaminase (ALT), gamma-glutamyl transferase (GGT), matrix metalloproteinase 7 (MMP-7), and total bile acids (TBA). We defined nonfunctioning HPE as persistent jaundice, cirrhosis, LT, or death. We calculated pooled serum variables, including hazard and odds ratios, for NLS using inverse variance weighting.
resultsThirty studies were included in the meta-analysis including a total of 4399 BA patients, 2073 and 1793 had successful versus nonfunctioning HPE, respectively. The mean HPE age for the successful group was significantly less (63.3 vs. 69.5 days, p < 0.001). TB was significantly elevated in the nonfunctioning group (p < 0.001). Pooled ALT and GGT were significantly lower in the successful group 1-3 months and >5 years after HPE (p < 0.001). The successful group had significantly lower serum TBA (27.55 vs. 69 μmol/L, p < 0.001) > 5 years after HPE.
conclusionEstablished serum values ALT, GGT, and TB are useful for prognostic assessment post-HPE. MMP-7 and TBA require additional evaluation to determine their prognostic relevance for NLS in BA.
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