ArticlePediatric pulmonology2026
Early Life Food Desert Status Is Associated With Alpha and Gamma-Tocopherol Levels and Infant Lung Function.
Article in Pediatric pulmonology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Comment on "Early Life Food Desert Status Is Associated With Alpha and Gamma Tocopherol Levels and Infant Lung Function".Pediatric pulmonology · 2026Article
- Comment on "Early Life Food Desert Status Is Associated With Alpha and Gamma-Tocopherol Levels and Infant Lung Function".Pediatric pulmonology · 2026Article
- Early Life Food Desert Status Is Associated With Alpha and Gamma-Tocopherol Levels and Infant Lung Function.Pediatric pulmonology · 2026Article
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Authors and funding
9 authors.
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Abstract
backgroundLiving in a food desert (an area with limited access to affordable and nutritious food) is associated with a higher prevalence of childhood asthma. There is a lack of information regarding the impact of spending the first year of life in a food desert on subsets of Vitamin E (α- and γ-tocopherol) levels and lung development.
objectiveDetermine if living in a food desert at 3 months of life is associated with altered α- and γ-tocopherol, and infant lung measurements.
designNewborns recruited within 1 week of delivery and prospectively followed for 3 months. 32 infants had sedated lung function tests and 50 had food desert data for analysis along with serum for α-tocopherol and γ-tocopherol analysis.
participantsFifty (50) infants within the prospective Indiana High-risk for Atopy in Neonates Cohort through Early life (INHANCE) were analyzed.
main outcome measuresLung function, serum tocopherol concentration, and food desert status from the INHANCE cohort were analyzed. Because α-tocopherol and γ-tocopherol have opposing mechanistic functions, and the combination of high α-tocopherol with low γ-tocopherol have been shown to associate with better lung function in 2- to 3-year olds and in adults, in this study of 3-month old infants, quadrants of high and low α-tocopherol and γ-tocopherol were assessed for association with food deserts and lung function tests. STATISTICAL ANALYSES PERFORMED: Fisher's Exact tests were used to compare food desert designations with quadrants, due to small counts. Analysis of Variance (ANOVA) models were used to compare lung function values across the four quadrants, and Student's t-tests were used to compare the lung function z-scores across the two-level quadrant groups.
resultsAt 3 months of age, lung volumes were lower in children living in food deserts (FVC: p = 0.006; FEV
conclusionNot living in a food desert is associated with the highest α- and lowest γ-tocopherol levels at 3 months of age. At 3 months of age, not living in a food desert was associated with higher lung function; with higher lung function associated with the highest α-tocopherol and lowest γ-tocopherol levels. Prospective trials are needed to determine if a lack of nutritious food during pregnancy and the first year of life is linked with decreased α-tocopherol and increased γ-tocopherol throughout this time period, and if this potential link is consistently associated with lower airway measurements that persist for the first few years of life.
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