Evidence map›Paper›PMID 41608868›Full record

ArticleeLife2026

Gut microbe-derived trimethylamine shapes circadian rhythms through the host receptor TAAR5.

Kala K Mahen, William J Massey, Danny Orabi, Amanda L Brown, Thomas C Jaramillo, Amy Burrows, Anthony J Horak, Sumita Dutta, Marko Mrdjen, Nour Mouannes and 17 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. TMAO Correlates with Transcriptomic Signatures of Leukocyte Activation and Systemic Inflammation Following Burn Injury.Journal of burn care & research : official publication of the American Burn Association · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Kala K MahenDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
William J MasseyCenter for Microbiome and Human Health, Cleveland Clinic, Cleveland, United States.
Danny OrabiDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
Amanda L BrownDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
Thomas C JaramilloRodent Behavior Core, Cleveland Clinic, Cleveland, United States.
Amy BurrowsDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
Anthony J HorakDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.ORCID https://orcid.org/0009-0009-2024-3679
Sumita DuttaDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
Marko MrdjenDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
Nour MouannesDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
Venkateshwari VaradharajanDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
Lucas J OsbornDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
Xiayan YeDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
Dante M YarbroughDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
Treg GrubbDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
Natalie ZajczenkoDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
Rachel HoheDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
Rakhee BanerjeeDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
Pranavi LingaDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
Dev LaunganiDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.
Adeline M HajjarCenter for Microbiome and Human Health, Cleveland Clinic, Cleveland, United States.
Naseer SangwanCenter for Microbiome and Human Health, Cleveland Clinic, Cleveland, United States.
Mohammed DwidarCenter for Microbiome and Human Health, Cleveland Clinic, Cleveland, United States.ORCID https://orcid.org/0000-0003-1366-0393
Jennifer A BuffaCenter for Microbiome and Human Health, Cleveland Clinic, Cleveland, United States.
Garth R SwansonDepartment of Medicine, Medical University of South Carolina, Charleston, United States.
Zeneng WangCenter for Microbiome and Human Health, Cleveland Clinic, Cleveland, United States.ORCID https://orcid.org/0000-0002-6455-8228
Jonathan Mark BrownDepartment of Cancer Biology, Cleveland Clinic, Cleveland, United States.ORCID https://orcid.org/0000-0003-2708-7487

Funding

Project Two - Exercise Training Decreases Alcohol Drinking by an FGF21-Dependent MechanismP50AA024333 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI Srinivasan Dasarathy · 2016 to 2026
$19.6M
Project 3: Microbiota generated aryl sulfates and secondary bile acids in cardiometabolic diseaseP01HL147823 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Stanley L Hazen · 2019 to 2026
$17.0M
Metaorganismal Endocrinology in Cardiometabolic DiseaseR01DK130227 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Jonathan Mark Brown · 2021 to 2026
$2.8M
Dark GPCR signaling underlying the Microbiome-Gut-Brain Axis for Alzheimer's Disease and Related DementiaRF1NS133812 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI BROWN, JONATHAN MARK, CHENG, FEIXIONG · 2023 to 2023
$2.3M
American Heart Association 10.58275/aha.24post1178494.pc.gr.190863NHLBI NIH HHS P01 HL147823NIAAA NIH HHS P50 AA024333NIDDK NIH HHS R01 DK130227NINDS NIH HHS RF1 NS133812
6 · The paper itself

Abstract

Elevated levels of the gut microbe-derived metabolite trimethylamine

Indexed as

Circadian RhythmGastrointestinal MicrobiomeMethylaminesReceptors, G-Protein-CoupledAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutTrace Amine-Associated ReceptorsMethylaminesReceptors, G-Protein-CoupledTrace Amine-Associated Receptorstrimethylaminetrimethyloxaminebiochemistrychemical biologycircadian rhythmmetabolismmicrobiomemouseolfaction

Identifiers

PMID41608868
PMCPMC12854671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.