ArticleDEN open2026
Clinicopathological Features of Superficial Non-Ampullary Duodenal Epithelial Tumors Involving Brunner's Glands.
Article in DEN open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Although Brunner's glands (BGs), located in the submucosa of the duodenum, may be involved by tumor cells of superficial non-ampullary duodenal epithelial tumors (SNADETs), the detailed incidence and histopathological features have not yet been analyzed. This study aimed to clarify the histopathological relationship between SNADETs and BGs. Methods: We retrospectively analyzed SNADETs that were resected at a single center between 2006 and 2021. Resected specimens were histologically evaluated to determine the presence and/or involvement of SNADET in BGs. The relationship between clinicopathological features and tumor involvement in BGs was also assessed. Results: In total, 114 lesions were included. Direct connection with BGs was seen in 52.6% of SNADETs, and submucosal BG involvement was observed in 7.0% (95% confidence interval 3.1%-13.4%) of SNADETs. The presence of submucosal BG involvement was significantly associated with 0-IIc morphology, high-grade dysplasia or carcinoma, and the gastric mucinous phenotype. The presence of either a lesion size 10 mm or greater or 0-IIc morphology demonstrated a sensitivity of 100%, a specificity of 34.9%, and a false negative rate of 0% for predicting submucosal BG involvement. Moreover, non-neoplastic BGs were exposed at the vertical margin in 15.1% of endoscopic resection specimens. Conclusion: SNADETs can have submucosal involvement via BGs, particularly in lesions fulfilling either a size ≥10 mm or a 0-IIc morphology. These pathological findings suggest that vertical resectability may be relevant in their endoscopic management, although further studies are needed to clarify clinical implications.
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