Evidence map›Paper›PMID 41608710›Full record

ArticleStroke (Hoboken, N.J.)2025

Revascularization Treatment of Basilar Artery Occlusion in Patients with Mild-to-Moderate Severe Stroke.

Simone Lieschke, Simon Hellwig, Christoph Riegler, Mirjam R Heldner, Marialuisa Zedde, Andrea Zini, Henrik Gensicke, Valerian L Altersberger, Corinne Inauen, Laurent Puy and 33 more

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In one paragraph

Article in Stroke (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Simone LieschkeDepartment of Neurology with Experimental Neurology Charité- Universitätsmedizin Berlin, Corporate Member of the Freie Universität Berlin and Humboldt-Universität Berlin Berlin Germany.ORCID https://orcid.org/0000-0001-9343-0242
Simon HellwigDepartment of Neurology with Experimental Neurology Charité- Universitätsmedizin Berlin, Corporate Member of the Freie Universität Berlin and Humboldt-Universität Berlin Berlin Germany.
Christoph RieglerDepartment of Neurology with Experimental Neurology Charité- Universitätsmedizin Berlin, Corporate Member of the Freie Universität Berlin and Humboldt-Universität Berlin Berlin Germany.
Mirjam R HeldnerDepartment of Neurology Inselspital Bern University Hospital and University of Bern Bern Switzerland.
Marialuisa ZeddeNeurology Unit Stroke Unit Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia Reggio Emilia Italy.
Andrea ZiniIRCCS Istituto delle Scienze Neurologiche di Bologna Department of Neurology and Stroke Center Maggiore Hospital Bologna Italy.
Henrik GensickeDepartment of Rehabilitation and Neurology University Department of Geriatric Medicine FELIX PLATTER, University of Basel Basel Switzerland.
Valerian L AltersbergerDepartment of Neurology and Stroke Center University Hospital Basel and University of Basel Basel Switzerland.
Corinne InauenDepartment of Neurology University Hospital Zurich and University of Zurich Zurich Switzerland.
Laurent PuyUniv. Lille, Inserm, CHU Lille, UMR-S1172 - LilNCog - Lille Neuroscience & Cognition Lille France.
Peter Arthur RinglebDepartment of Neurology University Hospital Heidelberg Heidelberg Germany.
Alexander SalernoStroke Center Service of Neurology Department of Clinical Neurosciences Lausanne University Hospital and University of Lausanne Lausanne Switzerland.
Yannick BéjotDepartment of Neurology Université Bourgogne Europe, University Hospital of Dijon Dijon France.
Alessandro PezziniDepartment of Medicine and Surgery University of Parma Parma Italy.
Visnja PadjenNeurology Clinic Clinical Centre of Serbia Faculty of Medicine University of Belgrade Belgrade Serbia.
Issa MetanisDepartment of Neurology Hadassah-Hebrew University Medical Center Jerusalem Israel.
João Pedro MartoDepartment of Neurology Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental Lisbon Portugal.
Paul J NederkoornDepartment of Neurology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands.
Carlo W CeredaStroke Center EOC Neurology Neurocenter of Southern Switzerland Lugano Switzerland.
Guido BigliardiStroke Unit Department of Neuroscience Ospedale Civile di Baggiovara Modena University Hospital Modena Italy.
George NtaiosFirst Propedeutic Department of Internal Medicine AHEPA University Hospital Aristotle University of Thessaloniki Thessaloniki Greece.
Heinrich J AudebertDepartment of Neurology with Experimental Neurology Charité- Universitätsmedizin Berlin, Corporate Member of the Freie Universität Berlin and Humboldt-Universität Berlin Berlin Germany.
Johannes KaesmacherInstitute of Diagnostic and Interventional Neuroradiology Inselspital, Bern University Hospital and University of Bern Bern Switzerland.
Rosario PascarellaNeuroradiology Unit Ospedale Santa Maria della Misericordia, AULSS 5 Polesana Rovigo Italy.
Matteo PaolucciIRCCS Istituto delle Scienze Neurologiche di Bologna Department of Neurology and Stroke Center Maggiore Hospital Bologna Italy.
Simon M TruesselDepartment of Rehabilitation and Neurology University Department of Geriatric Medicine FELIX PLATTER, University of Basel Basel Switzerland.
Stefan T EngelterDepartment of Rehabilitation and Neurology University Department of Geriatric Medicine FELIX PLATTER, University of Basel Basel Switzerland.
Susanne WegenerDepartment of Neurology University Hospital Zurich and University of Zurich Zurich Switzerland.
Charlotte CordonnierUniv. Lille, Inserm, CHU Lille, UMR-S1172 - LilNCog - Lille Neuroscience & Cognition Lille France.
Silvia SchönenbergerDepartment of Neurology University Hospital Heidelberg Heidelberg Germany.
Guillaume SaliouInterventional Neuroradiological Unit Service of Diagnostic and Interventional Radiology Department of Medical Radiology Lausanne University Hospital and University of Lausanne Lausanne Switzerland.
Gauthier DuloquinDepartment of Neurology Université Bourgogne Europe, University Hospital of Dijon Dijon France.
Mauro MagoniVascular Neurology Stroke Unit ASST Spedali Civili Brescia Italy.
Predrag StanarcevicNeurology Clinic Clinical Centre of Serbia Faculty of Medicine University of Belgrade Belgrade Serbia.
Ronen R LekerDepartment of Neurology Hadassah-Hebrew University Medical Center Jerusalem Israel.
Vitor Mendes FerreiraDepartment of Neurology Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental Lisbon Portugal.
Nabila WaliDepartment of Neurology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands.
Zeno BenciStroke Center EOC Neurology Neurocenter of Southern Switzerland Lugano Switzerland.
Francesca RosafioStroke Unit Department of Neuroscience Ospedale Civile di Baggiovara Modena University Hospital Modena Italy.
Ioannis IoannidisDepartment of Radiology University of Thessaly Larissa Greece.
Christian H NolteDepartment of Neurology with Experimental Neurology Charité- Universitätsmedizin Berlin, Corporate Member of the Freie Universität Berlin and Humboldt-Universität Berlin Berlin Germany.
Jan F ScheitzDepartment of Neurology with Experimental Neurology Charité- Universitätsmedizin Berlin, Corporate Member of the Freie Universität Berlin and Humboldt-Universität Berlin Berlin Germany.
TRISP and EVA‐TRISP collaborators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe benefit of endovascular thrombectomy (EVT) in patients with basilar artery occlusion and severe neurological deficits is well established. However, its effectiveness in those with mild-to-moderate deficits remains uncertain. This study compared outcomes of EVT(±intravenous thrombolysis [IVT]) versus IVT alone in patients with basilar artery occlusion and mild-to-moderate stroke severity.

methodsWe used data from the international multicenter EVA-TRISP (Endovascular Treatment and Thrombolysis for Ischemic Stroke Patients) and TRISP (Thrombolysis for Ischemic Stroke Patients) collaboration. All patients with radiologically confirmed basilar artery occlusion, National Institutes of Health Stroke Scale score <10, and a time to first treatment within 6 hours were included. Main outcomes of interest were favorable (functional) outcome (modified Rankin Scale [mRS] score 0-2), overall distribution of mRS, mortality at 3 months, and symptomatic intracranial hemorrhage. We applied binary logistic and ordinal regression using covariate adjustment and inverse probability of treatment weighting.

resultsAmong 274 patients from 18 centers, 176 (64.3%) received EVT (mean age 68±15 years, 38% female, median [interquartile range] National Institutes of Health Stroke Scale score 5 [3-8], 34% with bridging IVT) and 98 (35.8%) received IVT alone (mean age 70±13 years, 43% female, median National Institutes of Health Stroke Scale score 5 [4-8]). Favorable outcome occurred in 63.6% of patients with EVT(±IVT) and in 64.3% of patients with IVT alone (adjusted odds ratio [OR] 0.89, 95% CI 0.46-1.72). There was an association of EVT(±IVT) with unfavorable distribution of the mRS (adjusted OR 1.83, 95% CI 1.10-3.06), and mortality was higher in the EVT(±IVT) group (15.9% versus 6.1%, adjusted OR 3.38, 95% confidence interval 1.30-8.75). Rates of symptomatic intracranial hemorrhage did not differ between groups (2.0% versus 0%). The results remained unchanged after additional inverse probability of treatment weighting analyses.

conclusionsIn this multicenter observational cohort study, EVT(±IVT) in patients with basilar artery occlusion with mild-to-moderate stroke, was not associated with improved clinical outcome but higher mortality compared with IVT-treatment. Our findings underscore equipoise and the need for prospective trials in this population.

Indexed as

BAOEVTIVTminor strokestroke

Identifiers

PMID41608710
PMCPMC12697607

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