Evidence map›Paper›PMID 41608684›Full record

ArticleFrontiers in microbiology2025

Polymyxin-resistant hypervirulent

Xinyu Zhu, Jie Yan, Xiyun Lai, Tingjian Zou, Mengyuan Chen, Xiaofang Tang, Qiang Wang, Yuzhou He

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xinyu Zhu *The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China.
Jie Yan *The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China.
Xiyun LaiThe Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China.
Tingjian ZouThe Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China.
Mengyuan ChenDepartment of Clinical Laboratory, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Xiaofang TangDepartment of General Medicine, Zhejiang Hospital, Hangzhou, China.
Qiang WangDepartment of Clinical Laboratory, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Yuzhou HeDepartment of Emergency, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Polymyxins are critical last-resort treatments for infections caused by multidrug-resistant (MDR) gram-negative bacteria, especially carbapenem-resistant isolates. Recently, there has been a continuous increase in reports of polymyxin-resistant Methods: In this study, 17 PoRKP strains were retrospectively identified from 2,146 Results: The overall polymyxin resistance rate among the bacterial isolates included in this study was low (0.8%); however, all PoRKP isolates were MDR-positive. Notably, only three isolates carried Conclusion: Our findings indicated a relatively low prevalence of plasmid-mediated mobile polymyxin resistance genes among PoRKP isolates, whereas the upregulation of the two-component systems (particularly phoPQ) played a more prominent role in mediating polymyxin resistance.

Indexed as

hypervirulentmgrBPhoPQpolymyxin-resistant Klebsiella pneumoniaevirulence

Identifiers

PMID41608684
PMCPMC12838265

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.