Evidence map›Paper›PMID 41608654›Full record

ArticleWorld journal of stem cells2026

Dawn of a new era in olfactory regeneration: Pediatric stem cell therapy enters the era of long-term validation.

Guan-Yu Chen, Jia-Bing Kang, Yu-Kai Wang, Meng Liu

Abstract readLetter
In one paragraph

Article in World journal of stem cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guan-Yu ChenDepartment of Experimental Orofacial Medicine, Philipps-Universität Marburg, Marburg 35039, Germany.
Jia-Bing KangDepartment of Experimental Orofacial Medicine, Philipps-Universität Marburg, Marburg 35039, Germany.
Yu-Kai WangDepartment of Neurosurgery, Philipps-Universität Marburg, Marburg 91054, Germany.
Meng LiuDepartment of Pediatric Dentistry, Affiliated Stomatological Hospital of Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China. 578647325@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A recently published prospective study marks a breakthrough for congenital olfactory disorders in children. The study provides the first long-term, three-year follow-up data, robustly demonstrating the durable efficacy and safety of autologous nasal epithelial stem cell transplantation. This work reveals immense therapeutic potential for a condition traditionally considered untreatable. However, this milestone achievement also presents new challenges. To translate this pioneering therapy from a single-center success to a global standard, multicenter, controlled clinical trials must be initiated immediately. Only through rigorous validation can we ensure its widespread adoption and ultimately bring hope to millions of children worldwide.

Indexed as

Clinical translationCongenital olfactory disordersNasal epithelial stem cellsPediatric anosmiaRegenerative medicineStem cell therapy

Identifiers

PMID41608654
PMCPMC12836205

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.