Evidence map›Paper›PMID 41608620›Full record

ArticleInternational journal of biological sciences2026

Elaidic acid suppresses hepatocellular carcinoma growth through modulating the production of intestinal

Yini Li, Tongtong Tian, Qian Yu, Huiqin Jiang, Te Liu, Hao Wang, Ran Huo, Chenzheng Gu, Yu Liu, Ying Zhao and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yini LiDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Tongtong TianDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Qian YuDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Huiqin JiangDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Te LiuShanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hao WangDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Ran HuoDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Chenzheng GuDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Yu LiuDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Ying ZhaoDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Chunyan ZhangDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Yan ZhouDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Jiyan WangDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Lin DingDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Chuyu WangDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Xinyi HeDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Wei GuoDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Wenjing YangDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Beili WangDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary intervention provides a novel approach for cancer therapy. Elaidic acid (EA), which accounts for 80-90% of total trans fatty acids in foods, has recently been found to exert anti-tumor effects. However, the biological functions and underlying mechanisms of EA remain elusive in hepatocellular carcinoma (HCC). In this study, targeted fatty acid metabolomics demonstrated that among 44 types of fatty acids, the concentration of EA decreased most significantly when comparing plasma from HCC patients with plasma from healthy people. Through

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsOleic AcidsSpermidineAnimalsCell Line, TumorCell ProliferationHumansMaleMiceelaidic acidOleic AcidsSpermidineelaidic acidhepatocellular carcinomaLigilactobacillus murinusspermidine

Identifiers

PMID41608620
PMCPMC12839069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.