ArticleFrontiers in molecular neuroscience2025
Gene expression asymmetry in Parkinson's disease: variation of
Article in Frontiers in molecular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Parkinson's disease (PD) symptom onset is typically unilateral, which may be related to molecular differences underlying hemispheric vulnerability. Here we sampled prefrontal cortex bilaterally from people with PD and healthy controls and performed RNA-seq on neuronal nuclei to determine hemispheric and disease-related differences. Brain hemispheres were categorized based on whether they corresponded to the side of symptom onset (severe) or the opposite side (moderate) and compared for differences in gene expression. We employed two
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