Evidence map›Paper›PMID 41608586›Full record

ArticleTheranostics2026

PLK1 stabilizes β-catenin to drive colorectal carcinogenesis through NFKB2-mediated transcriptional activation of USP2a and site-specific phosphorylation.

Yan Li, Lili Zhao, Jiaqiang Deng, Songmei Lu, Jingyu Du, Chen Chen, Li Zhao, Zhiyun Xu, Wencan Wang, Yundi Wang and 1 more

Abstract read
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yan LiCollege of Life Sciences, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, Sichuan University, Chengdu, 610065, China.
Lili ZhaoCollege of Life Sciences, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, Sichuan University, Chengdu, 610065, China.
Jiaqiang DengCollege of Life Sciences, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, Sichuan University, Chengdu, 610065, China.
Songmei LuCollege of Life Sciences, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, Sichuan University, Chengdu, 610065, China.
Jingyu DuCollege of Life Sciences, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, Sichuan University, Chengdu, 610065, China.
Chen ChenCollege of Life Sciences, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, Sichuan University, Chengdu, 610065, China.
Li ZhaoCollege of Life Sciences, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, Sichuan University, Chengdu, 610065, China.
Zhiyun XuCollege of Life Sciences, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, Sichuan University, Chengdu, 610065, China.
Wencan WangCollege of Life Sciences, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, Sichuan University, Chengdu, 610065, China.
Yundi WangCollege of Life Sciences, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, Sichuan University, Chengdu, 610065, China.
Fangdong ZouCollege of Life Sciences, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, Sichuan University, Chengdu, 610065, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

beta CateninCarcinogenesisCell Cycle ProteinsColorectal NeoplasmsProtein Serine-Threonine KinasesProto-Oncogene ProteinsUbiquitin-Specific ProteasesAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMiceMice, NudePhosphorylationPolo-Like Kinase 1Protein Stabilitybeta CateninCell Cycle ProteinsCTNNB1 protein, humanPolo-Like Kinase 1Protein Serine-Threonine KinasesProto-Oncogene ProteinsUbiquitin-Specific ProteasesUbiquitin ThiolesteraseUSP2 protein, humancolorectal cancerNFKB2PLK1USP2aWnt signalingβ-catenin

Identifiers

PMID41608586
PMCPMC12846735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.