ReviewWorld journal of orthopedics2026
Advances in polymer-based hydrogel systems for adipose-derived mesenchymal stem cells toward bone regeneration.
Review in World journal of orthopedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Research Progress of Injectable Hydrogels Targeting Specific Pathogenesis for Osteonecrosis of the Femoral Head.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone regeneration for non-load-bearing defects remains a significant clinical challenge requiring advanced biomaterials and cellular strategies. Adipose-derived mesenchymal stem cells (AD-MSCs) have garnered significant interest in bone tissue engineering (BTE) because of their abundant availability, minimally invasive harvesting procedures, and robust differentiation potential into osteogenic lineages. Unlike bone marrow-derived mesenchymal stem cells, AD-MSCs can be easily obtained in large quantities, making them appealing alternatives for therapeutic applications. This review explores hydrogels containing polymers, such as chitosan, collagen, gelatin, and hyaluronic acid, and their composites, tailored for BTE, and emphasizes the importance of these hydrogels as scaffolds for the delivery of AD-MSCs. Various hydrogel fabrication techniques and biocompatibility assessments are discussed, along with innovative modifications to enhance osteogenesis. This review also briefly outlines AD-MSC isolation methods and advanced embedding techniques for precise cell placement, such as direct encapsulation and three-dimensional bioprinting. We discuss the mechanisms of bone regeneration in the AD-MSC-laden hydrogels, including osteoinduction, vascularization, and extracellular matrix remodeling. We also review the preclinical and clinical applications of AD-MSC-hydrogel systems, emphasizing their success and limitations. In this review, we provide a comprehensive overview of AD-MSC-based hydrogel systems to guide the development of effective therapies for bone regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.