Evidence map›Paper›PMID 41608498›Full record

ArticleWorld journal of orthopedics2026

Novel use of bisphosphonates to improve surgical outcomes in experimental bone tuberculosis.

Veronika V Petukhova, Alexander Yu Mushkin, Alexey S Maletin, Marine Z Dogonadze, Natalia V Zabolotnykh, Marina E Dyakova, Dilyara S Esmedlyaeva, Tatiana I Vinogradova, Mikhail M Kostik

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Article in World journal of orthopedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Veronika V PetukhovaDepartment of Pediatric Orthopedics and Surgery, Saint-Petersburg Research Institute of Phthisiopulmonology, Saint Petersburg 191036, Russia.
Alexander Yu MushkinDepartment of Pediatric Orthopedics and Surgery, Saint-Petersburg Research Institute of Phthisiopulmonology, Saint Petersburg 191036, Russia.
Alexey S MaletinDepartment of Pediatric Orthopedics and Surgery, Saint-Petersburg Research Institute of Phthisiopulmonology, Saint Petersburg 191036, Russia.
Marine Z DogonadzeResearch Laboratory of Microbiology, Biochemistry and Immunogenetics, Saint-Petersburg Research Institute of Phthisiopulmonology, Saint Petersburg 191036, Russia.
Natalia V ZabolotnykhResearch Laboratory of Experimental Medicine, Saint-Petersburg Research Institute of Phthisiopulmonology, Saint Petersburg 191036, Russia.
Marina E DyakovaResearch Laboratory of Microbiology, Biochemistry and Immunogenetics, Saint-Petersburg Research Institute of Phthisiopulmonology, Saint Petersburg 191036, Russia.
Dilyara S EsmedlyaevaResearch Laboratory of Microbiology, Biochemistry and Immunogenetics, Saint-Petersburg Research Institute of Phthisiopulmonology, Saint Petersburg 191036, Russia.
Tatiana I VinogradovaResearch Laboratory of Experimental Medicine, Saint-Petersburg Research Institute of Phthisiopulmonology, Saint Petersburg 191036, Russia.
Mikhail M KostikHospital Pediatrics, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia. kost-mikhail@yandex.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTuberculous osteitis is a chronic, granulomatous bone infection that frequently results in impaired bone healing following surgery. Despite surgical intervention and prolonged anti-tuberculous therapy, complete bone regeneration often remains unachieved, contributing to subsequent orthopedic complications.

aimTo investigate the efficacy and safety of pamidronate in promoting bone regeneration following surgical treatment of experimental animal tuberculous osteitis.

methodsA controlled randomized basic study of rabbit femoral tuberculosis induced by

resultsPamidronate treatment significantly reduced early implant resorption, increased osteoblastic activity, improved trabecular bone regeneration, and maintained graft integrity compared to the anti-tuberculous therapy-only group. Histologically, pamidronate led to enhanced vascular remodeling and increased bone matrix formation. Crucially, bisphosphonate therapy demonstrated safety, compatibility with anti-tuberculous medications, and did not exacerbate tuberculous inflammation. Furthermore, micro-computed tomography analysis revealed a significant increase in trabecular thickness and density in pamidronate-treated groups, underscoring the anabolic effects of bisphosphonates. Morphometric evaluation confirmed a marked reduction in osteoclast number and activity at graft interfaces. These combined radiological, histological, and biochemical data collectively demonstrate the efficacy of pamidronate as an adjunctive agent in enhancing bone repair outcomes following surgical intervention for tuberculous osteitis.

conclusionA single intravenous dose of pamidronate significantly enhances bone regeneration and prevents implant resorption following surgical treatment of tuberculous osteitis. The following prospective studies are needed.

Indexed as

BisphosphonatesBone and joint tuberculosisBone graftingBone regenerationBone resorptionPamidronateTuberculosis

Identifiers

PMID41608498
PMCPMC12836159

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