ArticleFrontiers in medicine2025
Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as prognostic factors in patients with colorectal cancer: a retrospective study.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Preoperative Immunonutritional Indices in Colorectal Cancer: The Contribution of Albumin, Time-Dependence of Effect, and Threshold Transportability in a Saudi Cohort.Current oncology (Toronto, Ont.) · 2026Article
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Authors and funding
7 authors.
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Abstract
Background: Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been investigated as potential prognostic biomarkers. This study aims to evaluate the association between NLR and PLR with CRC across age groups and assess their prognostic value for overall survival (OS) and cancer-specific survival (CSS). Materials and methods: This is a retrospective study conducted on 285 CRC patients who underwent elective colectomy. Sociodemographic and clinicopathological characteristics were collected from electronic records. Preoperative NLR and PLR were calculated from blood samples. Descriptive analyses, multivariable logistic regression analyses, and survival analyses using Cox regression and Kaplan-Meier tests were used. Results: The highest median NLR was 4.54 and found among the youngest age group (<50 years). High NLR, defined as a value ≥3.19, was associated with worse OS (HR 2.23, Conclusion: High NLR was identified as an independent prognostic factor for worse CSS in CRC patients. The association between NLR and PLR with CRC outcomes may vary across different age groups. These findings highlight the potential utility of NLR as a prognostic biomarker in CRC, particularly for CSS.
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