ArticleFrontiers in medicine2025
Case Report: Nebulized platelet-rich plasma facilitates resolution of post-infective pulmonary consolidation and cavitation in a lung cancer survivor.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Persistent lung consolidation and cavitary lesions are recognized sequelae of severe pneumonia, particularly in patients with prior oncologic or radiation-related lung injury. Platelet-rich plasma (PRP) contains growth factors and cytokines that promote tissue repair and immune modulation, yet its pulmonary application remains largely unexplored. Case presentation: A woman in her mid-40s with a history of stage IV right-lower-lobe non-small-cell lung cancer (NSCLC) in long-term remission developed severe pneumonia while overseas. Six weeks after discharge, a low-dose CT revealed persistent right-upper-lobe consolidation with internal lucency. She administered nebulized autologous PRP for 4 weeks using a compressor-based nebulizer. Results: Serial CT imaging demonstrated rapid reduction and eventual resolution of the consolidation with closure of a cavitary defect. The patient experienced no bronchial irritation or adverse effects. Conclusion: Nebulized autologous PRP was temporally associated with radiologic resolution of a post-infective cavitary lesion in a previously irradiated lung. This finding supports further study of PRP's regenerative potential in pulmonary disease.
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